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Fig. 5 | BMC Medicine

Fig. 5

From: Humoral immune response after different SARS-CoV-2 vaccination regimens

Fig. 5

Correlation of the surrogate neutralisation test (sVNT) results with results obtained by the laboratory-developed Vero-cell-based virus-neutralisation test (cVNT) using a B.1.1.7 strain as antigen (A). The Spearman correlation coefficient of log(reciprocal titre) was calculated with 0.88; empty circles: first vaccination; filled circles: second vaccination; red: heterologous vaccination with AZD1222/mRNA; green: homologous vaccination with AZD1222; blue: homologous vaccination with BNT162b2. Probability of detecting virus-neutralising antibodies (VNA) with the cVNT at a given percentage inhibition of sVNT calculated by logistic regression (B); e.g. at 20% inhibition (black dashed line), 63% inhibition (red dashed line), and at 87% inhibition of sVNT (green dashed line), the probabilities of detecting VNA with cVNT are 4% (95% confidence interval (CI) 1–16%), 50 % (95% CI 34–66 %) and 85% (95% CI 73–92%), respectively. The distribution of the cVNT titres, their medians, and their 95% CIs between the three plotted thresholds (dashed black, red and green lines in A, B) are shown (C)

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