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Table 3 Multivariable Mendelian randomization for age at first sex with risk of oropharyngeal cancer

From: Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

Exposure

Exposure dataset

N SNPs

Conditional

F-stat

Q-stat

P value for instrument validity

Method

AFS

OR

95% CI

P

Number of sexual partners

UK Biobank [26]

152

7.81

214.14

3.77 × 10-4

IVW

0.42

0.19, 0.94

0.04

      

MR-Egger

0.24

0.06, 1.01

0.05

Comprehensive Smoking Index

UK Biobank [53]

174

8.87

191.26

0.14

IVW

0.48

0.25, 0.95

0.03

 

MR-Egger

0.71

0.23, 2.19

0.56

Smoking initiation

GSCAN [51]

215

6.43

250.58

0.04

IVW

0.42

0.21, 0.83

0.01

 

MR-Egger

0.61

0.21, 1.74

0.35

Drinks per week

GSCAN [51]

147

28.88

164.77

0.11

IVW

0.72

0.43, 1.20

0.21

 

MR-Egger

0.43

0.14

1.28

Risk tolerance

UK Biobank [26]

160

13.68

171.18

0.21

IVW

0.53

0.30, 0.93

0.03

 

MR-Egger

0.24

0.08, 0.72

0.01

Educational attainment

SSAGC and UK Biobank [52]

317

7.91

319.62

0.28

IVW

0.74

0.39, 1.43

0.37

 

MR-Egger

0.79

0.33, 1.86

0.59

  1. Abbreviations: IVW, inverse variance weighted; AFS, age at first sex; OR, odds ratio; CI, confidence intervals; P p value; Q-stat, Cochran’s Q statistic; F-stat, conditional F-statistic; Social Science Genetic Association Consortium (SSGAC). AFS OR represents the odds ratio of oropharyngeal squamous cell carcinoma per SD change (7.3-month delay) in age at first sex