Fig. 7

A single dose of BNT162b2 induced significantly higher amounts of spike protein binding IgG, IgA, and receptor binding domain neutralizing antibodies than AZD1222. A SARS-CoV-2 spike binding antibodies were detected by ELISA and absorbance readouts were normalized to calibrator values to obtain arbitrary units. Gray lines depict the positive response threshold within a range of 0.8 to 1.1 arbitrary units. Sample sizes were n = 18 for AZD1222 and n = 18 for BNT162b2, respectively. p-values resulting from one-way ANOVA and Tukey-Kramer multiple comparisons tests were < 0.0001 for all three isotype analyses. B Neutralizing antibodies were determined by the surrogate virus competitive ELISA. Absorbance readouts from BNT162b2 (n = 17) and AZD1222 (n = 17) were calibrated with WHO standards to obtain international units (IU)/mL. *p < 0.05 resulting from Mann-Whitney U test and ***p < 0.001 resulting from Dunn’s test