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Table 2 Univariate analysis of overall survival in correlation with the biomarkers analyzed

From: Circulating tumor cell gene expression and plasma AR gene copy number as biomarkers for castration-resistant prostate cancer patients treated with cabazitaxel

  N. patients N. events Median OS (months)
(95% CI)
p (logrank) HR
(95% CI)
p
(Cox)
AR-V7
 Not expressed 63 48 16.4 (11.3–25.9)   1.00  
 Expressed 11 10 10.6 (1.3–16.7) 0.008 2.52 (1.24–5.12) 0.011
AKR1C3
 Not expressed 58 45 16.7 (12.4–22.7)   1.00  
 Expressed 16 13 9.6 (4.6–12.8) 0.028 2.01 (1.06–3.81) 0.031
AKT2
 Not expressed 60 45 15.2 (11.1–22.7)   1.00  
 Expressed 14 13 12.6 (5.0–18.1) 0.134 1.61 (0.86–3.00) 0.138
ALDH1
 Not expressed 67 54 14.0 (11.1–18.3)   1.00  
 Expressed 7 4 27.0 (1.3–nr) 0.428 0.66 (0.24–1.84) 0.432
AR
 Not expressed 56 43 18.1 (13.0–25.9)   1.00  
 Expressed 18 15 7.6 (3.7–12.4) 0.001 2.70 (1.46–5.01) 0.002
EPCAM
 Not expressed 37 25 25.9 (16.4–39.1)   1.00  
 Expressed 37 33 9.8 (6.8–12.4) < 0.0001 3.75 (2.10–6.71) < 0.0001
PSMA
 Not expressed 48 36 18.1 (13.3–28.0)   1.00  
 Expressed 26 22 10.2 (7.2–13.0) 0.009 2.09 (1.19–3.66) 0.010
MDK
 Not expressed 54 40 18.3 (13.3–27.0)   1.00  
 Expressed 20 18 8.3 (3.9–12.4) < 0.0001 3.35 (1.83–6.13) < 0.0001
PIK3CA
 Not expressed 50 39 16.4 (11.1–22.7)   1.00  
 Expressed 24 19 12.8 (5.2–22.0) 0.337 1.31 (0.75–2.28) 0.339
PSCA
 Not expressed 64 50 15.2 (11.7–22.6)   1.00  
 Expressed 10 8 5.7 (1.3–16.4) 0.088 1.92 (0.90–4.10) 0.092
TUBB3
 Not expressed 69 54 14.3 (11.3–22.0)   1.00  
 Expressed 5 4 3.1 (1.3–nr) 0.146 2.10 (0.75–5.86) 0.155
VIM
 Not expressed 14 13 11.5 (3.9–25.9)   1.00  
 Expressed 60 45 15.2 (11.1–22.6) 0.105 0.60 (0.32–1.12) 0.109
PARP
 Not expressed 56 43 16.7 (11.3–22.7)   1.00  
 Expressed 18 15 10.5 (4.6–15.2) 0.112 1.61 (0.89–2.91) 0.117
POU5F
 Not expressed 47 38 15.2 (11.3–22.6)   1.00  
 Expressed 27 20 12.8 (6.8–34.4) 0.757 1.09 (0.63–1.88) 0.758
HPRT1
 Not expressed 44 33 18.3 (14.1–28.0)   1.00  
 Expressed 30 25 8.6 (3.9–12.4) 0.0006 2.46 (1.44–4.18) 0.0009
  1. Abbreviations: pts patients, OS overall survival, CI confidence interval, HR hazard ratio, nr not reached