Table 2 Univariate analysis of overall survival in correlation with the biomarkers analyzed
N. patients | N. events | Median OS (months) (95% CI) | p (logrank) | HR (95% CI) | p (Cox) | |
|---|---|---|---|---|---|---|
AR-V7 | ||||||
Not expressed | 63 | 48 | 16.4 (11.3–25.9) | 1.00 | ||
Expressed | 11 | 10 | 10.6 (1.3–16.7) | 0.008 | 2.52 (1.24–5.12) | 0.011 |
AKR1C3 | ||||||
Not expressed | 58 | 45 | 16.7 (12.4–22.7) | 1.00 | ||
Expressed | 16 | 13 | 9.6 (4.6–12.8) | 0.028 | 2.01 (1.06–3.81) | 0.031 |
AKT2 | ||||||
Not expressed | 60 | 45 | 15.2 (11.1–22.7) | 1.00 | ||
Expressed | 14 | 13 | 12.6 (5.0–18.1) | 0.134 | 1.61 (0.86–3.00) | 0.138 |
ALDH1 | ||||||
Not expressed | 67 | 54 | 14.0 (11.1–18.3) | 1.00 | ||
Expressed | 7 | 4 | 27.0 (1.3–nr) | 0.428 | 0.66 (0.24–1.84) | 0.432 |
AR | ||||||
Not expressed | 56 | 43 | 18.1 (13.0–25.9) | 1.00 | ||
Expressed | 18 | 15 | 7.6 (3.7–12.4) | 0.001 | 2.70 (1.46–5.01) | 0.002 |
EPCAM | ||||||
Not expressed | 37 | 25 | 25.9 (16.4–39.1) | 1.00 | ||
Expressed | 37 | 33 | 9.8 (6.8–12.4) | < 0.0001 | 3.75 (2.10–6.71) | < 0.0001 |
PSMA | ||||||
Not expressed | 48 | 36 | 18.1 (13.3–28.0) | 1.00 | ||
Expressed | 26 | 22 | 10.2 (7.2–13.0) | 0.009 | 2.09 (1.19–3.66) | 0.010 |
MDK | ||||||
Not expressed | 54 | 40 | 18.3 (13.3–27.0) | 1.00 | ||
Expressed | 20 | 18 | 8.3 (3.9–12.4) | < 0.0001 | 3.35 (1.83–6.13) | < 0.0001 |
PIK3CA | ||||||
Not expressed | 50 | 39 | 16.4 (11.1–22.7) | 1.00 | ||
Expressed | 24 | 19 | 12.8 (5.2–22.0) | 0.337 | 1.31 (0.75–2.28) | 0.339 |
PSCA | ||||||
Not expressed | 64 | 50 | 15.2 (11.7–22.6) | 1.00 | ||
Expressed | 10 | 8 | 5.7 (1.3–16.4) | 0.088 | 1.92 (0.90–4.10) | 0.092 |
TUBB3 | ||||||
Not expressed | 69 | 54 | 14.3 (11.3–22.0) | 1.00 | ||
Expressed | 5 | 4 | 3.1 (1.3–nr) | 0.146 | 2.10 (0.75–5.86) | 0.155 |
VIM | ||||||
Not expressed | 14 | 13 | 11.5 (3.9–25.9) | 1.00 | ||
Expressed | 60 | 45 | 15.2 (11.1–22.6) | 0.105 | 0.60 (0.32–1.12) | 0.109 |
PARP | ||||||
Not expressed | 56 | 43 | 16.7 (11.3–22.7) | 1.00 | ||
Expressed | 18 | 15 | 10.5 (4.6–15.2) | 0.112 | 1.61 (0.89–2.91) | 0.117 |
POU5F | ||||||
Not expressed | 47 | 38 | 15.2 (11.3–22.6) | 1.00 | ||
Expressed | 27 | 20 | 12.8 (6.8–34.4) | 0.757 | 1.09 (0.63–1.88) | 0.758 |
HPRT1 | ||||||
Not expressed | 44 | 33 | 18.3 (14.1–28.0) | 1.00 | ||
Expressed | 30 | 25 | 8.6 (3.9–12.4) | 0.0006 | 2.46 (1.44–4.18) | 0.0009 |