Fig. 5
From: Systematic review of Mendelian randomization studies on risk of cancer
Network of the exposure–cancer associations of the Mendelian randomization analyses presenting robust evidence. Note: For circulating telomere length, the red arrows refer to longer while the green arrows refer to shorter genetically predicted telomere length. For HMG-GoA reductase, the green arrow to ovarian cancer refers to decreased genetically predicted levels of the exposure. Abbreviations: AC: adenocarcinoma; BMI: body mass index; ER−: estrogen receptor negative; ER+: estrogen receptor positive; FEV1: forced expiratory volume in one second; HDL: high-density lipoprotein; HMG-CoA: 3-Hydroxy-3-methylglutaryl coenzyme A; IGF-1: insulin-like growth factor 1; LDL: low-density lipoprotein; SCC: squamous cell carcinoma; SHBG: sex-hormone-binding globulin