Table 1 Characteristics of the outcome dataset of individuals of white British ancestry in the UK Biobank

N

(N=321,024)

(N=172,289)

(N=148,735)

Age (years)

58 [51;63]

58 [50;63]

59 [51;64]

Sex

 Female

172,289 (54%)

172,289 (100.00%)

0 (0%)

 Male

148,735 (46%)

0 (0.0%)

148,735 (100%)

Body mass index (kg/m²)

26.7 [24.1;29.8]

26.1 [23.4;29.6]

27.3 [25.0;30.0]

 Obesity (>  30 kg/m²)

77,051 (24%)

39,635 (23%)

37,416 (25%)

Hypertension medication

66,676 (21%)

29,946 (17%)

36,730 (25%)

 Systolic BP (mmHg)

136.5 [125;149.5]

133.5 [121.5;147.5]

139.5 [129;152]

 Diastolic BP (mmHg)

82 [75.5;89]

80 [73.5;87]

84 [77.5;90.5]

Diabetes mellitus

15,368 (5%)

5830 (3%)

9538 (6%)

 Hemoglobin A1c (mmol/L)

35.1 [32.7;37.7]

35.1 [32.7;37.6]

35.2 [32.7;37.9]

Dyslipidemia medication

55,731 (17%)

21,609 (13%)

34,122 (23%)

 Triglycerides (mmol/L)

1.49 [1.05;2.16]

1.34 [0.97;1.90]

1.70 [1.19;2.45]

 LDL cholesterol (mmol/L)

3.53 [2.96;4.13]

3.59 [3.02;4.20]

3.47 [2.88;4.06]

 HDL cholesterol (mmol/L)

1.40 [1.18;1.68]

1.56 [1.33;1.83]

1.24 [1.07;1.46]

eGFR (creatinine, mL/min/1.73 m²)

92.50 [82.61;99.54]

92.86 [82.59;99.79]

92.16 [82.62;99.25]

 <  30

301 (0.1%)

127 (0.1%)

174 (0.1%)

 ≥ 30 and <  60

7063 (2.2%)

3781 (2.2%)

3282 (2.2%)

 ≥ 60 and <  90

126,376 (39.4%)

66,615 (38.7%)

59,761 (40.2%)

 ≥ 90 and <  120

186,747 (58.2%)

101,584 (59.0%)

85,163 (57.3%)

 ≥ 120

537 (0.2%)

182 (0.1%)

355 (0.2%)

eGFR (cystatin C, mL/min/1.73 m²)

88.89 [77.13;100.48]

89.85 [77.48;100.92]

87.88 [76.72;99.73]

 <  30

519 (0.2%)

214 (0.1%)

305 (0.2%)

 ≥ 30 and <  60

14,365 (4.5%)

7602 (4.4%)

6763 (4.6%)

 ≥ 60 and <  90

153,403 (47.8%)

78,858 (45.8%)

74,545 (50.1%)

 ≥ 90 and <  120

151,157 (47.1%)

84,976 (49.3%)

66,181 (44.5%)

 ≥ 120

1580 (0.5%)

639 (0.4%)

941 (0.6%)

Myocardial infarction

13,205 (4%)

3111 (2%)

10,094 (7%)