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Fig. 5 | BMC Medicine

Fig. 5

From: Effects of personalized diets by prediction of glycemic responses on glycemic control and metabolic health in newly diagnosed T2DM: a randomized dietary intervention pilot trial

Fig. 5

Gut microbiome composition associates with clinical outcomes. A Per participant distributions of microbial taxa relative abundances at baseline. Colors indicate bacterial taxa according to the legend on the right. Participants are sorted by baseline HbA1c levels, presented as gray bars at the bottom. Microbiome diversity (Shannon Diversity Index) is illustrated with a dashed line, using a 5-person rolling average, indicating a negative association with HbA1c levels. B Heatmap of significant associations across all (n = 16) participants (p < 0.05, FDR corrected) between changes in microbial taxa (rows) and changes in clinical outcomes (columns) over the 6-month intervention period. C Correlation between 6-month change in FPG and 6-month change in Firmicutes/Bacteroidetes ratio. Dots represent participants, with color indicating weight loss in kilograms. D Correlation between change in HbA1c and change in propionate-producing bacteria over the 6-month intervention period. Dots represent participants, with color indicating weight loss in kilograms. E Change in the relative abundance of Blautia between baseline and 6 months after the intervention started (p < 0.05, FDR corrected). Shown is the average reduction in the relative abundance of Blautia genus across all participants (red line) and change per participant (gray lines)

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