Reader number | True negative | True positive | CP ↓ PDACa | PDAC ↓ CPb | Sensitivity (%) | Specificity (%) | |
---|---|---|---|---|---|---|---|
Internal validation cohort | 1 | 33→28 | 52→70↑ | 23 | 0 | 71.2→95.9↑* | 91.7→77.8 |
2 | 19→27↑ | 65→73↑ | 9 | 9 | 89.0→100.0↑* | 52.8→75.0↑* | |
3 | 22→27↑ | 70→73↑ | 3 | 5 | 95.9→100.0↑ | 61.1→75.0↑ | |
4 | 32→33↑ | 63→69↑ | 6 | 1 | 86.3→94.5↑* | 88.9→91.7↑ | |
5 | 22→33↑ | 58→64↑ | 5 | 13 | 79.5→84.2↑ | 61.1→91.7↑* | |
External validation cohort 1 | 1 | 5→8↑ | 34→36↑ | 4 | 5 | 87.2→92.3↑ | 45.5→72.7↑ |
2 | 8→8 | 31→34↑ | 4 | 1 | 79.5→87.2↑ | 72.7→72.7 | |
3 | 10→10 | 33→35↑ | 2 | 0 | 84.6→89.7↑ | 90.9→90.9 | |
4 | 10→10 | 33→36↑ | 3 | 0 | 84.6→92.3↑ | 90.9→90.9 | |
5 | 8→9↑ | 28→33↑ | 9 | 5 | 71.8→84.6↑ | 72.7→81.8↑ | |
External validation cohort 2 | 1 | 7→7 | 31→35↑ | 6 | 2 | 81.6→92.1↑ | 70.0→70.0 |
2 | 6→6 | 32→35↑ | 3 | 0 | 84.2→92.1↑ | 60.0→60.0 | |
3 | 9→8 | 31→35↑ | 7 | 2 | 81.6→92.1↑ | 90.0→80.0 | |
4 | 6→8↑ | 34→36↑ | 2 | 2 | 89.5→94.7↑ | 60.0→80.0↑ | |
5 | 7→4 | 29→36↑ | 13 | 3 | 76.3→94.7↑* | 70.0→40.0 |