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Table 3 DGBI diagnoses in subjects grouped by frequency of meal-related abdominal pain

From: Global prevalence and burden of meal-related abdominal pain

Diagnosis

Frequency of meal-related abdominal pain

No (n = 9756)

Occasional (n = 12,377)

Frequent (n = 5932)

Esophageal disorders

6.6 (6.1, 7.1)

9.4 (8.9, 9.9)

20.2 (19.1, 21.2)

 Functional chest pain

2.3 (2.0, 2.6)

2.1 (1.9, 2.4)

2.7 (2.3, 3.1)

 Functional heartburn

0.9 (0.7, 1.1)

1.9 (1.7, 2.2)

6.1 (5.5, 6.7)

 Reflux hypersensitivity

0.7 (0.6, 0.9)

1.3 (1.1, 1.5)

5.3 (4.7, 5.9)

 Globus

1.1 (0.9, 1.3)

0.8 (0.7, 1.0)

1.1 (0.9, 1.4)

 Functional dysphagia

2.6 (2.3, 2.9)

5.2 (4.8, 5.6)

13.7 (12.9, 14.6)

Gastroduodenal disorders

9.4 (8.9–10.0)

19.4 (18.7, 20.1)

35.0 (33.8, 36.2)

 Functional dyspepsia (n = 3834)

5.7 (5.2, 6.2)

12.8 (12.2, 13.4)

28.6 (27.5, 29.8)

  Postprandial distress syndrome

86.5 (83.7, 89.4)

80.7 (78.7, 82.6)

79.9 (78.0, 81.8)

  Epigastric pain syndrome

21.8 (18.3, 21.2)

36.0 (33.6, 38.3)

56.7 (54.4, 59.1)

 Belching disorder

0.7 (0.5, 0.9)

1.5 (1.3, 1.7)

5.2 (4.7, 5.8)

 Chronic nausea and vomiting syndrome

0.7 (0.5, 0.8)

1.7 (1.5, 1.9)

4.5 (4.0, 5.0)

 Cyclic vomiting syndrome

0.6 (0.5, 0.8)

2.6 (2.3, 2.9)

5.5 (4.9, 6.1)

 Cannabinoid hyperemesis syndrome

0.0 (0.0, 0.0)

0.0 (0.0, 0.1)

0.4 (0.2, 0.5)

 Rumination syndrome

2.9 (2.6, 3.3)

5.3 (5.0, 5.8)

5.9 (5.3, 6.5)

Bowel disorders

36.5 (35.6, 37.5)

51.5 (50.6, 52.4)

69.5 (68.3, 70.6)

 Irritable bowel syndrome (n = 2616)

2.3 (2.0, 2.6)

7.3 (6.8, 7.8)

25.1 (24.0, 26.2)

  IBS-C

30.1 (24.2, 0.365)

32.2 (29.1, 35.3)

31.9 (29.5, 34.3)

  IBS-D

27.4 (21.7, 33.7)

27.7 (24.8, 30.8)

29.4 (27.1, 31.8)

  IBS-M

33.2 (27.1, 39.7)

32.5 (29.5, 35.7)

34.1 (31.7, 36.6)

  IBS-U

9.3 (5.8, 13.9)

7.5 (5.9, 9.5)

4.6 (3.6, 5.8)

 Functional constipation

13.7 (13.0, 14.4)

18.0 (17.3, 18.7)

18.1 (17.1, 19.1)

 Functional diarrhea

4.7 (4.3, 5.1)

6.4 (5.9, 6.8)

7.8 (7.2, 8.6)

 Functional abdominal bloating/distention

4.3 (3.9, 4.7)

5.3 (4.9, 5.7)

5.1 (4.6, 5.7)

 Unspecified functional bowel disorder

11.0 (10.4, 11.6)

13.0 (12.5, 13.7)

11.9 (11.1, 12.8)

 Opioid-induced constipation

1.1 (0.9, 1.3)

3.5 (3.2, 3.8)

4.7 (4.2, 5.3)

 Central abdominal pain syndrome

0.1 (0.0, 0.2)

0.0 (0.0, 0.1)

0.0 (0.0, 0.1)

Biliary pain

0.1 (0.1, 0.2)

0.1 (0.1, 0.2)

0.3 (0.2, 0.5)

Anorectal disorders

7.4 (6.9, 8.0)

14.3 (13.7, 15.0)

25.2 (24.1, 26.3)

 Fecal incontinence

1.1 (0.9, 1.4)

2.8 (2.5, 3.1)

6.4 (5.8, 7.1)

 Levator Ani syndrome

1.2 (1.0, 1.4)

1.8 (1.6, 2.1)

5.5 (4.9, 6.1)

 Proctalgia Fugax

5.4 (5.0, 5.9)

11.0 (10.4, 11.5)

16.9 (16.0, 17.9)

  1. The proportion of subjects fulfilling the Rome IV criteria for a DGBI in “no” (0% of the abdominal pain episodes were meal-related), “occasional” (10–40% of the abdominal pain episodes were meal-related), and “frequent” (≥ 50% of the abdominal pain episodes were meal-related) group was determined within each group. The rows containing the main DGBI categories indicate the proportion of subjects fulfilling the diagnostic criteria of at least one esophageal, gastroduodenal, bowel, and anorectal disorder. Within the subgroups of functional dyspepsia and irritable bowel syndrome, proportions were calculated based on the total number of functional dyspepsia and irritable bowel syndrome patients, respectively. Data are presented as percentage (95% confidence interval)
  2. DGBI Disorder of the gut-brain interaction, IBS-C Irritable bowel syndrome with predominant constipation, IBS-D Irritable bowel syndrome with predominant diarrhea, IBS-M Irritable bowel syndrome with mixed bowel habits, IBS-U Irritable bowel syndrome unsubtyped
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BMC Medicine

ISSN: 1741-7015

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