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Table 1 Demographic and baseline characteristics

From: Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

 

Africa

Asia

South America

N (%) or median (range)

N (%) or median (range)

N (%) or median (range)

Number of patients evaluated

50,859

18,451

916

Age (years)

3 (0.03–86.7)

16 (0.2–88.0)

23 (3.1–65.0)

Age group

 < 1 year

4562 (9.0)

67 (0.4)

0 (0)

 1–4 years

31,225 (61.4)

2071 (11.2)

2 (0.2)

 5–11 years

9103 (17.9)

4524 (24.5)

111 (12.1)

 ≥ 12 years

5969 (11.7)

11,789 (63.9)

803 (87.7)

Sexa

 Female

24,432 (48.9)

7054 (38.2)

350 (38.2)

 Male

25,566 (51.1)

11,397 (61.8)

566 (61.8)

Haemoglobin (g/dL)b

9.9 (5.0–19.7)

11 (5.0–20.0)

12.3 (6.9–17.9)

Haematocrit (%)c

31.6 (10.0–54.0)

36.3 (14.4–55.0)

37.3 (18–54.1)

Derived haemoglobin (g/dL)d

9.9 (5.0–19.7)

11.6 (5.0–20.0)

12.3 (6.9–17.9)

Anaemia

 Moderately severe anaemia (haemoglobin < 7 g/dL)

4284 (8.4)

606 (3.3)

1 (0.1)

 Moderate anaemia (haemoglobin 7–< 10 g/dL)

21,676 (42.6)

4260 (23.1)

78 (8.5)

 No anaemia (haemoglobin ≥ 10 g/dL)

24,899 (49.0)

13,585 (73.6)

837 (91.4)

Temperature (°C)e

38 (34.0–42.0)

37.7 (34.0–42.0)

37.5 (35.1–42.0)

 Fever (temperature > 37.5 °C)

32,266 (65.9)

8937 (54.2)

438 (48.0)

Parasitaemia (/μL)

21,600 (2.5–486,080)

9375 (7–499,712)

4490 (8–149,925)

 High parasitaemia (> 100,000/μl)

5200 (10.2)

1548 (8.4)

3 (0.3)

Presence of gametocytaemiaf

2339 (8.2)

1530 (11.2)

107 (11.8)

Underweight (WAZ < − 2)g

6205 (18.8)

781 (39.0)

2 (100)

Species of infection

 Mixed P. falciparum and P. vivax

0 (0)

1151 (6.2)

0 (0)

 P. falciparum mono-infection

50,859 (100)

17,300 (93.8)

916 (100)

Transmission setting

 High

19,766 (38.9)

0 (0)

0 (0)

 Moderate

15,357 (30.2)

561 (3.0)

0 (0)

 Low

15,736 (30.9)

17,890 (97.0)

916 (100)

Treatment

 Artemisinin-based

36,823 (72.5)

16,086 (87.2)

821 (89.6)

 Non-artemisinin-based

13,935 (27.5)

2360 (12.8)

95 (10.4)

  1. Total number of patients enrolled in Africa was 50,859, Asia was 18,451 and South America was 916
  2. aData on patient sex were only available for 49,998 patients from Africa
  3. bData on baseline haemoglobin were only available for 47,778 patients from Africa and 7139 patients from Asia
  4. cData on baseline haematocrit were only available for 13,244 patients from Africa and 13,892 patients from Asia
  5. dThe following conversion from haematocrit was used: haemoglobin = (haematocrit − 5.62)/2.60
  6. eData on baseline temperature were only available for 48,982 patients from Africa and 16,483 patients from Asia
  7. fData on baseline gametocytes were only available for 28,453 patients from Africa, 13,697 patients from Asia and 904 patients from South America
  8. gData on weight-for-age Z-scores (WAZ) were only available for 33,048 patients from Africa, 2001 patients from Asia and 2 patients from South America. WAZ was only evaluated in children < 5 years