Table 2 Risk factors for moderately severe anaemia (Hb < 7 g/dL) at day 7: Multivariable logistic regression
Parameter | Africa | Asia | ||||
|---|---|---|---|---|---|---|
% (Number with moderately severe anaemia/N) | AOR (95% CI) | P value | % (Number with moderately severe anaemia/N) | AOR (95% CI) | P value | |
Age group | ||||||
 < 1 year | 16.9% (177/1045) | 12.81 (6.79–24.17) | < 0.001 | 9.7% (3/31) | 6.79 (2.36–19.58) | < 0.001 |
 1–4 years | 6.5% (651/10,086) | 6.09 (3.33–11.13) | < 0.001 | 7.3% (63/861) | 2.87 (1.84–4.47) | < 0.001 |
 5–11 years | 3.6% (101/2826) | 4.41 (2.30–8.48) | < 0.001 | 3.5% (83/2341) | 2.35 (1.56–3.52) | < 0.001 |
 ≥ 12 years | 0.7% (18/2706) | Reference |  | 1.3% (91/6898) | Reference |  |
Sex | ||||||
 Female | 5.2% (415/8058) | 0.80 (0.69–0.93) | 0.004 | 3.2% (124/3884) | 1.51 (1.15–1.99) | 0.003 |
 Male | 6.2% (532/8605) | Reference |  | 1.9% (116/6247) | Reference |  |
Fever | ||||||
 Yes | 7.0% (700/10,062) | 1.66 (1.33–2.09) | < 0.001 | 2.7% (148/5578) | 1.26 (0.92–1.71) | 0.152 |
 No | 3.7% (247/6601) | Reference |  | 2.0% (92/4553) | Reference |  |
Moderately severe anaemia at day 0 | ||||||
 Yes | 42.4% (383/904) | 16.10 (12.59–20.60) | < 0.001 | 32.6% (78/239) | 23.00 (14.27–37.06) | < 0.001 |
 No | 3.6% (564/15,759) | Reference |  | 1.6% (162/9892) |  |  |
High parasitaemiaa | ||||||
 Yes | 9.4% (152/1621) | 1.78 (1.42–2.24) | < 0.001 | 3.9% (35/900) | 1.58 (1.10–2.27) | 0.013 |
 No | 5.3% (795/15,042) | Reference |  | 2.2% (205/9231) | Reference |  |
Mixed infection | ||||||
 Yes | 0% (0/0) |  |  | 1.5% (11/717) | 0.44 (0.24–0.80) | 0.007 |
 No | 5.7% (947/16,663) |  |  | 2.4% (229/9414) | Reference |  |
Treatment | ||||||
 Artemisinin-based | 5.5% (841/15,209) | 1.01 (0.56–1.82) | 0.987 | 2.5% (225/8958) | 2.06 (1.39–3.05) | < 0.001 |
 Non-artemisinin-based | 7.3% (106/1454) | Reference |  | 1.3% (15/1173) | Reference |  |