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Table 3 Effect of parasite clearance time on moderately severe anaemia after treatment

From: Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

 

Africa

Asia

% (Number with moderately severe anaemia/Na)

AOR (95% CI)

P value

% (Number with moderately severe anaemia/Na)

AOR (95% CI)

P value

Moderately severe anaemia on day 3

 Clearance between day 0 and day 1

6.5% (221/3410)

Reference

 

4.4% (39/889)

Reference

 

 Clearance between day 1 and day 2

11.0% (473/4299)

1.52 (1.20–1.92)

0.001

6.5% (41/628)

1.16 (0.57–2.36)

0.685

 Clearance between day 2 and day 3

15.0% (94/626)

2.26 (1.55–3.29)

< 0.001

6.3% (16/254)

2.04 (0.76–5.47)

0.156

 Clearance after day 3

11.5% (9/78)

2.04 (0.82–5.09)

0.126

2.5% (5/197)

0.67 (0.06–7.08)

0.742

Moderately severe anaemia on day 7

 Clearance between day 0 and day 1

4.8% (243/5106)

Reference

 

1.6% (52/3177)

Reference

 

 Clearance between day 1 and day 2

6.1% (417/6834)

1.02 (0.76–1.35)

0.916

2.7% (100/3759)

1.32 (0.87–2.01)

0.187

 Clearance between day 2 and day 3

8.4% (99/1182)

1.28 (0.88–1.85)

0.199

2.8% (26/938)

1.57 (0.92–2.68)

0.102

 Clearance after day 3

12.4% (44/354)

2.44 (1.59–3.75)

< 0.001

2.9% (10/346)

2.59 (1.20–5.58)

0.015

  1. Effects are adjusted for all independent predictors identified in the final multivariable models for Africa and Asia in Table 2 (Main text) and Additional file 3: Table S8
  2. AOR adjusted odds ratio
  3. aN number of patients for each variable/levels of factors