Table 1 Lead SNPs (with genome-wide significant signals) associated with FG, HbA1C, QUICKI, and eGFR
Trait | Lead SNPs | Gene/nearest gene | Chr | Positiona | Effect allele | Beta | SE | P value |
|---|---|---|---|---|---|---|---|---|
eGFR | rs73985808 | ERBB4 | 2 | 212565932 | A | − 0.08 | 0.01 | 4.6 × 10−08 |
eGFR | rs13037490 | CST9 | 20 | 23583725 | C | 0.08 | 0.01 | 2.4 × 10−13 |
FG | rs11120828 | CAMTA1 | 1 | 7122846 | A | 0.14 | 0.02 | 1.6 × 10−10 |
FG | rs76150693 | 2 | 228526473 | G | 0.33 | 0.042 | 4.4 × 10−08 | |
FG | rs79451541 | NDUFA10 | 2 | 240929777 | A | 1.03 | 0.18 | 1.2 × 10−08 |
FG | rs74591871 | 3 | 20241645 | A | 0.196 | 0.036 | 4.9 × 10−08 | |
FG | rs78223279 | TRIO | 5 | 14397518 | A | 0.68 | 0.19 | 8.3 × 10−09 |
FG | rs115873798 | WWC1 | 5 | 167759448 | G | 0.25 | 0.04 | 3.4 × 10−08 |
FG | rs73231408 | 8 | 24930722 | T | 0.75 | 0.12 | 2.2 × 10−08 | |
FG | rs147360587 | TRAPPC9 | 8 | 141360595 | C | 0.23 | 0.04 | 5.6 × 10−09 |
FG | rs143653828 | SH3GL2 | 9 | 17580151 | T | 0.31 | 0.05 | 5.4 × 10−11 |
FG | rs77023105 | 12 | 30658931 | G | 0.33 | 0.06 | 3.2 × 10−08 | |
FG | rs72802149 | ABCC11 | 16 | 48197315 | T | 0.6 | 0.1 | 2.7 × 10−09 |
HbA1C | rs11120828 | CAMTA1 | 1 | 7122846 | A | 0.16 | 0.02 | 4.4 × 10−11 |
HbA1C | rs77145902 | 2 | 121862595 | T | 0.28 | 0.05 | 1.9 × 10−08 | |
HbA1C | rs117580692 | ME1 | 6 | 83955807 | A | 1.45 | 0.25 | 2.4 × 10−08 |
HbA1C | rs72941612 | PAK1 | 11 | 77059870 | T | 0.32 | 0.05 | 9.1 × 10−09 |
HbA1C | rs146006303 | RORA | 15 | 61137932 | C | 1.13 | 0.16 | 9.7 × 10−12 |
QUICKI | rs184544915 | METTL16 | 17 | 2329349 | C | 0.49 | 0.08 | 6.3 × 10−09 |