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Table 3 Comparison of the effect of estimated glomerular filtration rate difference among different endpoints

From: The impact of kidney function in patients on antithrombotic therapy: a post hoc subgroup analysis focusing on recurrent bleeding events from the AFIRE trial

 

Effect due to estimated glomerular filtration rate, 50 mL/min

95% CI

P value

Hazard ratio for the first bleeding

 Unadjusted

0.830

0.670–1.028

.088

 Adjusted

0.875

0.701–1.090

.234

Hazard ratio for the first event among the composite of bleeding, ischemic cardiovascular event, and any cause of death

 Unadjusted

0.677

0.567–0.809

.000

 Adjusted

0.723

0.603–0.867

.000

Rate ratios for recurrent bleeding

 Poisson (unadjusted)

0.738

0.615–0.886

.001

 Negative binomial (adjusted)

0.860

0.680–1.088

.208

Rate ratios for composite of recurrent bleeding, the first ischemic cardiovascular event, and any cause of death

 Poisson (unadjusted)

0.616

0.531–0.716

.000

 Negative binomial (adjusted)

0.742

0.615–0.896

.002

  1. CI Confidential interval