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Table 1 Characteristics of patients receiving symptomatic FIT tests by study inclusion status and outcome

From: Combining faecal immunochemical testing with blood test results for colorectal cancer risk stratification: a consecutive cohort of 16,604 patients presenting to primary care

 

All FIT tests

Included

Cancer

 

n

%

n

%

n

%

Total

18,656

100

16,604

100

139

100

Age

 0-18

95

1

0

0

0

0

 18-39.9

1,651

9

1,390

8

9

6

 40-49.9

2,553

14

2,278

14

12

9

 50-59.9

4,679

25

4,181

25

20

14

 60-69.9

3,186

17

2,892

17

21

15

 70-79.9

3,711

20

3,330

20

36

26

 ≥ 80

2,781

15

2,533

15

41

29

 Median (IQR)

61

(50, 74)

61

(51, 75)

72

(57, 81)

Sex

 Male

7,926

42

7,019

42

83

60

 Female

10,728

58

9,585

58

56

40

 Unknown

2

0

0

0

0

0

FIT (µg Hb/g)

      

 0-1.9

15,298

82

13,757

83

5

4

 2-9.9

1,409

8

1,318

8

6

4

 10-99.9

1,072

6

1,023

6

51

37

 ≥ 100

539

3

506

3

77

55

 Missing

338

2

0

0

  

 Median (IQR)

0

(0, 0.7)

0.2

(0, 0.8)

135.5

(33.4, 450)

Blood test results*

 Low haemoglobina

5,186

31

5,076

31

72

52

 High plateletsb

556

3

546

3

13

9

 High white cellsc

832

5

820

5

9

6

 Low mean cell haemoglobind

2,792

17

2,730

16

47

34

 Low mean cell volumee

1,014

6

980

6

30

22

 Any abnormal FBC

6,521

35

6,392

38

81

58

 Low serum ferritinf

2,015

22

1,962

22

36

40

 High serum ferriting

457

5

444

5

3

3

 High C-reactive proteinh

1,748

14

1,720

14

31

31

Clinical indication - GP reported

 Abdominal pain

3,299

18

2,941

18

23

17

 Blood in stool

1,759

9

1,451

9

22

16

 Melaena

298

2

238

1

0

0

 Change in bowel habit 

7,511

40

6,656

40

45

32

 Diarrhoea

2,651

14

2,315

14

13

9

 Constipation

722

4

608

4

1

1

 Fatigue

199

1

193

1

1

1

 Rectal pain

106

1

95

1

0

0

 Bloating

594

3

541

3

2

1

 Family history of cancer

342

2

263

2

2

1

 Weight loss

1,448

8

1,348

8

9

6

Blood - GP reported

 Anaemia (any)

4,517

24

4,272

26

48

35

 Iron deficiency anaemia

1,926

10

1,793

11

18

13

 Thrombocytosis

216

1

204

1

2

1

  1. Any abnormal full blood count (FBC) refers to any abnormal result of heamoglobin, platelets, white cells, mean cell haemoglobin and mean cell volume
  2. Note: Serum ferritin and c-reactive protein tests were only conducted for a subset of patients (n = 8,922 and 12,201 respectively)
  3. IQR Interquartile range
  4. *percent with non-missing values
  5. a <130 g/L in men and <120 g/L in women
  6. b >400 μL/L
  7. c >11,000/mL
  8. d <27.4 pg/cell
  9. e <80 fL
  10. f <20 ng/mL
  11. g ≥350 ng/mL
  12. h >10 mg/L