Table 2 Test performance as measured by positive and negative predictive value (PPV, NPV), sensitivity, specificity, positive FITs per cancer detected, and cancer miss rate per 10,000 negative tests. FIT alone and threshold-based approach to FIT-blood test pairs

FIT alone

FIT≥2 µg Hb/g

4.7% (4.0, 5.5)

100.0% (99.9, 100)

96.4% (91.9, 98.5)

83.5% (82.9, 84.1)

21

4

FIT≥10 µg Hb/g

8.4% (7.1, 9.9)

99.9% (99.9, 100)

92.1% (86.4, 95.5)

91.5% (91.1, 91.9)

12

7

FIT-Blood Test Pairs

FIT≥2 µg Hb/g AND

Low haemoglobin^a

5.1% (4.3, 6.2)

99.9% (99.8, 99.9)

89.1% (82.2, 93.5)

83.4% (82.7, 84.0)

17

44

High platelets^b

5.8% (4.6, 7.3)

99.6% (99.4, 99.7)

51.1% (42.9, 59.2)

93.0% (92.6, 93.4)

11

77

High white cells^c

8.7% (5.2, 14.4)

92.8% (91.5, 93.9)

9.4% (5.5, 15.3)

92.3% (91.0, 93.4)

29

80

Low mean cell haemoglobin^d

3.4% (1.7, 6.6)

99.2% (99.1, 99.3)

5.8% (2.9, 10.9)

98.6% (98.4, 98.8)

12

57

Low mean cell volume^e

8.0% (6.1, 10.5)

99.4% (99.3, 99.5)

33.8% (26.5, 42.0)

96.7% (96.4, 97.0)

66

Any abnormal FBC

15.9% (11.4, 21.8)

99.3% (99.2, 99.4)

21.6% (15.6, 29.1)

99.0% (98.9, 99.2)

19

40

Low serum ferritin^f

5.4% (4.3, 6.7)

99.6% (99.5, 99.7)

56.8% (48.5, 64.8)

91.6% (91.1, 92.0)

10

63

High serum ferritin^g

10.0% (7.3, 13.6)

99.4% (99.2, 99.5)

40.0% (30.5, 50.3)

96.3% (95.9, 96.7)

33

99

High C-reactive protein^h

3.0% (1.0, 8.5)

99.0% (98.8, 99.2)

3.3% (1.1, 9.3)

98.9% (98.7, 99.1)

18

59

FIT≥10 µg Hb/g AND

Low haemoglobin^a

5.6% (4.0, 7.8)

99.4% (99.3, 99.5)

31.0% (22.8, 40.6)

95.7% (95.3, 96.0)

10

44

High platelets^b

10.3% (8.2, 12.8)

99.6% (99.4, 99.7)

49.6% (41.5, 57.8)

96.4% (96.1, 96.6)

8

77

High white cells^c

12.2% (7.1, 20.2)

99.2% (99.1, 99.4)

8.6% (5.0, 14.5)

99.5% (99.4, 99.6)

17

80

Low mean cell haemoglobin^d

5.8% (2.9, 10.9)

99.2% (99.1, 99.3)

5.8% (2.9, 10.9)

99.2% (99.1, 99.3)

7

58

Low mean cell volume^e

13.5% (10.3, 17.6)

99.4% (99.3, 99.5)

32.4% (25.2, 40.5)

98.3% (98.0, 98.4)

4

67

Any abnormal FBC

23.3% (16.7, 31.7)

99.3% (99.2, 99.4)

20.1% (14.3, 27.6)

99.4% (99.3, 99.5)

10

39

Low serum ferritin^f

9.6% (7.7, 11.8)

99.6% (99.5, 99.7)

55.4% (47.1, 63.4)

95.6% (95.3, 95.9)

6

62

High serum ferritin^g

17.0% (12.5, 22.6)

99.4% (99.2, 99.5)

40.0% (30.5, 50.3)

98.0% (97.7, 98.3)

15

98

High C-reactive protein^h

6.5% (2.2, 17.5)

99.0% (98.8, 99.2)

3.3% (1.1, 9.3)

99.5% (99.3, 99.6)

13

62