Table 2 Adverse obstetric and neonatal outcomes in the CIN during pregnancy group and the treated group, compared to the normal cytology group, unadjusted and adjusted multivariable logistic regression analyses

PTD, <37 weeks

1794 (4.2)

74 (5.4)

1.28 (1.01–1.63)

0.041

1.21 (0.95–1.55)

0.12

244 (7.5)

1.84 (1.60–2.11)

<0.001

1.75 (1.51–2.01)

<0.001

Early PTD, <34 weeks

488 (1.2)

15 (1.1)

0.94 (0.56–1.58)

0.83

0.88 (0.52–1.49)

0.64

75 (2.3)

2.03 (1.59–2.59)

<0.001

1.93 (1.50–2.49)

<0.001

Very early PTD, <28 weeks

91 (0.2)

6 (0.4)

2.03 (0.89–4.65)

0.09

1.99 (0.86–4.61)

0.11

15 (0.5)

2.16 (1.25–3.73)

0.006

2.06 (1.17–3.63)

0.012

Spontaneous PTD

1264 (3.0)

49 (3.6)

1.20 (0.90–1.60)

0.22

1.13 (0.84–1.51)

0.43

194 (6.0)

2.07 (1.77–2.41)

<0.001

2.00 (1.70–2.34)

<0.001

pPROM

479 (1.1)

20 (1.4)

1.29 (0.82–2.02)

0.27

1.22 (0.78–1.92)

0.39

105 (3.2)

2.92 (2.36–3.62)

<0.001

2.63 (2.11–3.28)

<0.001

PROM, delivery at ≥ 37 weeks

2084 (5.1)

69 (5.3)

1.03 (0.81–1.32)

0.81

0.95 (0.74–1.21)

0.66

208 (6.9)

1.37 (1.19–1.59)

<0.001

1.23 (1.06–1.43)

0.008

SGA^b

894 (2.1)

35 (2.5)

1.21 (0.86–1.70)

0.28

1.11 (0.78–1.56)

0.57

65 (2.0)

0.95 (0.74–1.22)

0.68

0.89 (0.69–1.15)

0.37

Apgar score <7 at 5 min

476 (1.1)

16 (1.2)

1.03 (0.63–1.71)

0.90

0.99 (0.60–1.64)

0.97

37 (1.1)

1.01 (0.72–1.42)

0.94

0.98 (0.70–1.38)

0.90

Neonatal mortality

43 (0.1)

1 (0.1)

0.71 (0.10–5.19)

0.74

0.70 (0.10–5.17)

0.73

2 (0.1)

0.61 (0.15–2.51)

0.49

0.66 (0.16–2.75)

0.57

Intrauterine fetal death

88 (0.2)

2 (0.1)

0.70 (0.17–2.84)

0.62

0.66 (0.16–2.70)

0.56

7 (0.2)

1.04 (0.48–2.24)

0.93

1.07 (0.49–2.34)

0.87

Chorioamnionitis

97 (0.2)

5 (0.4)

1.59 (0.64–3.90)

0.32

1.43 (0.58–3.54)

0.44

14 (0.4)

1.89 (1.08–3.31)

0.027

1.57 (0.89–2.80)

0.12

Intrapartum fever

300 (0.7)

9 (0.7)

0.92 (0.47–1.79)

0.81

0.77 (0.39–1.50)

0.44

20 (0.6)

0.87 (0.55–1.37)

0.54

0.68 (0.43–1.07)

0.09

Neonatal sepsis

591 (1.4)

22 (1.6)

1.15 (0.75–1.76)

0.53

1.01 (0.66–1.56)

0.95

64 (2.0)

1.42 (1.10–1.84)

0.008

1.20 (0.92–1.56)

0.18