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Table 3 Adverse obstetric and neonatal outcomes in the treated group, compared to the CIN during pregnancy group, unadjusted and adjusted multivariable logistic regression analyses

From: Associations between cervical intraepithelial neoplasia during pregnancy, previous excisional treatment, cone-length and preterm delivery: a register-based study from western Sweden

Outcome

CIN during pregnancy group

(N=1380)

Treated group

(N=3092)a

Unadjusted analyses

Adjusted analysesb

n (%)

n (%)

OR (95% CI)

p value

aOR (95% CI)

p value

PTD <37 weeks

74 (5.4)

239 (7.7)

1.48 (1.13–1.93)

0.004

1.60 (1.21–2.12)

0.001

Early PTD <34 weeks

15 (1.1)

74 (2.4)

2.23 (1.28–3.90)

0.005

2.36 (1.32–4.23)

0.004

Very early PTD <28 weeks

6 (0.4)

15 (0.5)

1.12 (0.43–2.88)

0.82

0.90 (0.33–2.49)

0.84

Spontaneous PTD

49 (3.6)

189 (6.1)

1.77 (1.28–2.44)

<0.001

1.95 (1.40–2.72)

<0.001

pPROM

20 (1.4)

103 (3.3)

2.34 (1.45–3.80)

0.001

2.74 (1.66–4.51)

<0.001

PROM, delivery at ≥ 37 weeks

69 (5.3)

205 (7.2)

1.39 (1.05–1.84)

0.022

1.38 (1.03–1.85)

0.030

SGAc

35 (2.5)

63 (2.0)

0.80 (0.53–1.22)

0.30

0.88 (0.56–1.37)

0.57

Apgar score <7 at 5 min

16 (1.2)

37 (1.2)

1.03 (0.57–1.86)

0.92

1.00 (0.54–1.85)

1.00

Neonatal mortality

1 (0.1)

2 (0.1)

0.89 (0.08–9.85)

0.93

0.74 (0.06–9.07)

0.81

Intrauterine fetal death

2 (0.1)

7 (0.2)

1.56 (0.32–7.54)

0.58

1.62 (0.31–8.42)

0.57

Chorioamnionitis

5 (0.4)

14 (0.5)

1.25 (0.45–3.48)

0.67

1.35 (0.46–4.00)

0.58

Intrapartum fever

9 (0.7)

19 (0.6)

0.94 (0.43–2.09)

0.88

0.68 (0.29–1.57)

0.37

Neonatal sepsis

22 (1.6)

62 (2.0)

1.26 (0.77–2.06)

0.35

1.35 (0.81–2.25)

0.25

  1. Statistically significant p values in bold type
  2. a158 women also had a previous delivery in the CIN during pregnancy group and were excluded from the treated group in the analyses
  3. bAnalyses adjusted for: year of delivery, maternal age, parity, BMI, marital status, country of birth, infant’s sex, smoking, income, education level and assisted reproduction
  4. cMissing data: CIN during pregnancy group, n=0, treated group, n=2
  5. aOR, adjusted odds ratio; CI, confidence interval; CIN, cervical intraepithelial neoplasia; N, number; OR, odds ratio; pPROM, preterm prelabor rupture of membranes; PROM, prelabor rupture of membranes; PTD, preterm delivery; SGA, small for gestational age