High polygenic predisposition for ADHD and a greater risk of all-cause mortality: a large population-based longitudinal study

Table 3 Cox regression analyses highlighting associations between PGS-ADHD_multi-trait and risk for all-cause mortality during a follow-up period

Polygenic scores for ADHD	The whole sample				Men				Women
Polygenic scores for ADHD	HR	95% CI	p	R²	HR	95% CI	p	R²	HR	95% CI	p	R²
Participants all ages
PGS-ADHD_multi-trait	1.11	1.06–1.16	< 0.001	0.07%	1.10	1.03–1.18	0.003	0.09%	1.11	1.04–1.19	0.003	0.05%
Participants aged 50–75 years at start
PGS-ADHD_multi-trait	1.14	1.07–1.21	< 0.001	0.11%	1.14	1.05–1.25	0.002	0.24%	1.13	1.03–1.24	0.014	0.03%

Model was adjusted for baseline age, sex, interaction between age, sex and first 4 PCs to adjust for genetic ancestry; to capture non-linear effects of ageing, we included age² and age³ as covariates
ADHD attention deficit hyperactivity disorder, HR hazard ratio, CI confidence intervals

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