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Fig. 5 | BMC Medicine

Fig. 5

From: Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand

Fig. 5

The association between presence of PEXEL motifs and estimated half-life of total IgG antibodies, and the presence of TMD and the estimated half-life of IgG1-producing long-lived ASCs in the Thai symptomatic population. The kinetics of total IgG antibody against 52 IgG-immunogenic P. vivax antigens were determined following symptomatic P. vivax infections in Thai individuals in the absence of recurrent infections for 9 months. Mathematical modelling was then used to generate the estimated half-life of total IgG and IgG1-producing long-lived ASCs. The presence of PEXEL and TMDs was predicted for each P. vivax antigen using the online servers: PlasmoDB (https://plasmodb.org/plasmo/app) and Transmembrane Helices Hidden Markov Model (TMHMM) Server version 2.0 (http://www.cbs.dtu.dk/services/TMHMM/). Wilcoxon tests (non-parametric) were performed to compare between antigens with (Yes) and without (No) PEXEL or TMD. p value less than 0.05 was considered significant

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