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Fig. 2 | BMC Medicine

Fig. 2

From: Developing sero-diagnostic tests to facilitate Plasmodium vivax Serological Test-and-Treat approaches: modeling the balance between public health impact and overtreatment

Fig. 2

Exploration of the parameter space for the ROC curve of PvSeroTAT in a low transmission setting, with a single round of intervention using a hypothetical optimal hypnozoiticidal drug. A The red square on the full ROC curve represents the parameter space explored as part of the target product profiling. The three triangles correspond to a diagnostic test at 80% sensitivity and specificity (solid color; currently achieved by our antibody panel) as well as two alternatives at 65% and 90% (transparency; tradeoffs between sensitivity and specificity). B Association between impact (prevalence reduction after 6 months) and sensitivity. C Association between overtreatment and specificity. In panels B and C, dots are colored according to the diagnostic criteria not used on the x-axis

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BMC Medicine

ISSN: 1741-7015

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