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Table 1 Summary of drug accessibility, adherence, efficacy, and counter-indications across all three envisioned scenarios. The “best-case” scenario corresponds to a hypothetical drug that achieves 100% clearance of liver-stage parasites and does not pose any threat to health regardless of various deficiencies. The “High efficacy” scenario presents parameters corresponding to those observed in a clinical trial with administration of high-dose primaquine (7mg/kg total dose administered over 7 days) to clear liver-stages in eligible patients [11]. The “Real-life” scenario depicts the typical parameter values observed in Brazil where primaquine (3.5mg/kg total dose administered over 7 days) is routinely administered for P. vivax

From: Developing sero-diagnostic tests to facilitate Plasmodium vivax Serological Test-and-Treat approaches: modeling the balance between public health impact and overtreatment

 

Best-case

High efficacy

Real-life

G6PD deficiency

4.6%

4.6%

4.6%

CYP2D6 slow metabolizers

3.4%

3.4%

3.4%

Pregnancy

7.5%

7.5%

7.5%

Coverage

 Case-management

100%

80%

80%

 Intervention

80%

80%

80%

Bloodstage drug

 Efficacy (alone)

100%

100%

89.9%

 Efficacy (with anti-hpz)

100%

100%

94.6%

 Prophylaxis duration

28 days

28 days

14 days

Hypnozoiticidal drug

 Efficacy

100%

80%

71.36%

 Prophylaxis duration

28 days

8 days

8 days

 Adherence

100%

80%

66.7%

 Minimum age

0 days

180 days

180 days

 Pregnancy

administer

don't administer

don't administer

 G6PD deficiency

administer

don't administer

don't administer

 CYP2D6 slow metabolizers

effective

not effective

not effective