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Table 1 Baseline demographic and biochemical characteristics

From: Ezetimibe combination therapy with statin for non-alcoholic fatty liver disease: an open-label randomized controlled trial (ESSENTIAL study)

 

Ezetimibe + rosuvastatin (n = 34)

Rosuvastatin alone (n = 36)

p-value

Demographics

 Age, years

50.3 (12.9)

52.5 (19.1)

0.647

 Female; n (%)

12 (35.3)

18 (50.0)

0.214

 Weight, kg

78.2 (19.3)

77.2 (15.5)

0.958

 BMI, kg/m2

27.7 (6.6)

28.6 (3.6)

0.196

 Waist circumference, cm

95.0 (15.3)

96.5 (11.1)

0.685

 Presence of diabetes, n (%)

26 (72.2)

26 (76.5)

0.684

 Seated SBP, mmHg

126.0 (11.0)

123.0 (13.0)

0.676

 Seated DBP, mmHg

81.0 (11.0)

80.5 (13.0)

0.851

Biochemical profile

 ALT, IU/l

37.5 (30.0)

30.0 (22.0)

0.099

 AST, IU/l

24.5 (13.0)

24.5 (13.0)

0.706

 Platelets, ×103/μl

263.0 (89.0)

258.5 (77.0)

0.307

 Alk Phos, U/l

64.0 (22.0)

68.5 (36.0)

0.121

 GGT, U/l

42.5 (36.0)

35.0 (33.0)

0.347

 Total bilirubin, mg/dl

0.6 (0.3)

0.7 (0.4)

0.557

 Glucose, mg/dl

116.0 (26.0)

114.0 (35.0)

0.958

 Insulin, uU/ml

12.4 (10.3)

14.7 (9.1)

0.171

 HbA1c, %

6.4 (0.5)

6.4 (0.9)

0.548

 FFA, mmol/l

509.0 (307.0)

532.5 (260.0)

0.541

 HOMA-IR

3.5 (3.5)

3.9 (2.7)

0.166

 HOMA-beta

85.5 (70.3)

99.6 (60.4)

0.347

 Triglycerides, mg/dl

176.5 (143.0)

217.5 (159.0)

0.177

 HDL, mg/dl

45.0 (16.0)

42.0 (8.0)

0.266

 LDL, mg/dl

115.3 (64.7)

111.2 (39.9)

0.742

 CRP, mg/l

1.5 (1.8)

1.5 (1.5)

0.897

 eGFR, CKD-EPI equation

102.0 (23.0)

95.5 (28.0)

0.347

  1. Data are expressed as median (IQR) unless indicated as number (%) with p-values from the Mann-Whitney U test or χ2 analysis
  2. Abbreviations: BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT gamma-glutamyl transferase, FFA free fatty acids, HOMA-IR homeostatic model assessment of insulin resistance, HDL high-density lipoprotein, LDL low-density lipoprotein, CRP C-reactive protein, eGFR estimated glomerular filtration rate