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Table 2 The associations between asthma diagnosed at different ages and attained adult heights

From: The influence of childhood asthma on adult height: evidence from the UK Biobank

 

Full cohort (n = 149,610)

Men cohort (n = 86,250)

Women cohort (n = 63,360)

 

No. of individuals

Attained adult height (cm), mean (SD)

β (95% CI)a

No. of individuals

Attained adult height (cm), mean (SD)

β (95% CI)a

No. of individuals

Attained adult height (cm), mean (SD)

β (95% CI)a

p for sex differenceb

Unexposed group

136,008

171 (9.24)

0 (ref)

78,408

176 (6.76)

0 (ref)

57,600

163 (6.27)

0 (ref)

 

Exposed group, by age at asthma diagnosis (years)

 ≤ 2

1150

169 (8.98)

− 0.98 (− 1.34~− 0.62)

599

175 (6.91)

− 1.42 (− 1.93~− 0.90)

551

162 (6.10)

− 0.51 (− 1.00~− 0.01)

0.012

 3–4

1783

169 (9.11)

− 0.80 (− 1.09~− 0.51)

950

175 (6.51)

− 0.97 (− 1.38~− 0.56)

833

162 (6.36)

− 0.60 (− 1.01~− 0.20)

0.211

 5–6

2325

171 (9.28)

− 0.38 (− 0.64~− 0.13)

1420

176 (6.73)

− 0.38 (-0.71~− 0.04)

905

163 (6.45)

− 0.40 (-0.79~− 0.02)

0.939

 7–9

2650

171 (9.31)

− 0.36 (− 0.59~− 0.12)

1649

176 (6.64)

− 0.26 (− 0.57~0.05)

1001

163 (6.49)

− 0.51 (− 0.88~− 0.14)

0.310

 10–12

2621

172 (9.35)

− 0.25 (− 0.49~− 0.01)

1684

177 (6.70)

− 0.13 (− 0.43~0.18)

937

163 (6.40)

− 0.49 (− 0.88~− 0.11)

0.152

 13-18

3073

170 (9.50)

− 0.27 (− 0.49~− 0.05)

1540

177 (6.90)

− 0.04 (− 0.37~0.28)

1533

163 (6.30)

− 0.52 (− 0.82~− 0.22)

0.035

p for trendc

  

< 0.001

  

0.005

  

< 0.001

0.015

  1. CI confidence interval
  2. aβ were estimates derived from linear mixed-effect models stratified by matching identifiers (birth year, sex, and recruitment center) and adjusted for birth weight, Townsend deprivation index, education level, and annual household income
  3. bThe statistical significance of the difference between sexes was assessed by including an interaction term in the linear model
  4. cp values for dose-response trends were calculated by fitting ordinal exposure variables as continuous terms into the linear models