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Table 2 Sample size of the exposure (N), F statistic and the number of SNPs (nSNPs) used within the primary analysis

From: The relationships between women’s reproductive factors: a Mendelian randomisation analysis

Exposure

N

F statistic

R2

nSNPs

Age at menarche

243,898

74.95 (75.28 for outcome AFS)

0.064

223 (222 for outcome AFSa)

Age at menopause

143,791

85.08

0.047

84

Age at first live birth

203,606

41.97

8.38 × 10−3

41

Age at last live birth

203,356

43.46

1.92 × 10−3

9

Number of live births

250,746

46.75

1.68 × 10−3

9

Age first had sexual intercourse

219,486

39.46

9.44 × 10−3

53

Lifetime number of sexual partners

208,274

39.20

6.36 × 10−3

34

Ever parous status

250,746

53.92

8.59 × 10−4

4

  1. AFS age first had sexual intercourse. aOne palindromic SNP was excluded from the MR between age at menarche and AFS