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Table 3 Follow-up of participants who initially received a negative test result

From: Detection of SARS-CoV-2 infection in the general population by three prevailing rapid antigen tests: cross-sectional diagnostic accuracy study

 

Phase 1 (Ag-RDT result communicated)

Phase 2 (molecular test result communicated)

Initial test result negative, n

4847

2461

 Initial test result false negative, n (%)

168 (3.5)

n/aa

 Initial test result true negative, n (%)

4697 (96.5)

n/aa

At least one subsequent SARS-CoV-2 test registered within 14 daysb, n (%)

887 (18.3)

284 (11.5)

 Initial test result false negative, n (%)

103 (61.3)

n/aa

 Initial test result true negative, n (%)

784 (16.8)

n/aa

SARS-CoV-2-positive test within 14 days, n (%)

213 (4.4)

28 (1.1)

 Initial test result false negative, n (%)

93 (55.4)

n/aa

 Initial test result true negative, n (%)

120 (2.6)

n/aa

Stratified analysis according to symptomology at time of initial testing

 Initial test result negative, n

4715c

2392d

  Symptomatic, n (%)

2893 (61.4)

1427 (59.7)

  Asymptomatic, n (%)

1822 (38.6)

965 (40.3)

 Initial test result false negative, n

161

n/aa

  Symptomatic, n (%)

91 (56.5)

n/aa

  Asymptomatic, n (%)

70 (43.5)

n/aa

 Initial test result true negative, n

4554

n/aa

  Symptomatic, n (%)

2802 (61.5)

n/aa

  Asymptomatic, n (%)

1752 (38.5)

n/aa

 SARS-CoV-2-positive test within 14 days

  

 Initial test result negative

-

-

  Symptomatic, n (%)

87 (3.0)

12 (0.8) *

  Asymptomatic, n (%)

114 (6.3)

16 (1.7) *

 Initial test result false negative

-

 

  Symptomatic, n (%)

42 (46.2)**

n/aa

  Asymptomatic, n (%)

44 (62.9)**

n/aa

 Initial test result true negative

-

 

  Symptomatic, n (%)

45 (1.6)***

n/aa

  Asymptomatic, n (%)

70 (4.0)***

n/aa

  1. Ag-RDT rapid lateral flow antigen diagnostic tests, n/a not applicable
  2. aNot applicable since the molecular reference test result was communicated in phase 2
  3. bBased on pseudonymised linkage to SARS-CoV-2 test results database of the public health service test sites
  4. cSymptom status not available for 132 participants
  5. dSymptom status not available for 69 participants
  6. *χ2 =3.3, p=.068
  7. **χ2 =4.4, p=.035
  8. ***χ2 =25, p<.001