Table 5 The reasons for apatinib dose change (safety set, n = 32)
Reasons | Dose escalation failure (n = 10) | Discontinuation (n = 7) |
|---|---|---|
Hypertension, n (%) | 5 (50.0%) | 1 (14.3%) |
Neutropenia, n (%) | 4 (40.0%) | 0 |
Thrombocytopenia, n (%) | 2 (20.0%) | 2 (28.6%) |
Fatigue, n (%) | 3 (30.0%) | 0 |
Anorexia, n (%) | 3 (30.0%) | 0 |
Hand-foot syndrome, n (%) | 1 (10.0%) | 0 |
Elevation of ALT/AST, n (%) | 0 | 2 (28.6%) |
Emergency surgery, n (%) | 0 | 1 (14.3%) |
Disease progression, n (%) | 0 | 1 (14.3%) |