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Table 3 RBD-ACE2 affinity measured by MST. All experiments were performed in titration in triplicates and analyzed by the MO Affinity Analysis software (NanoTemper) by Hill fit

From: Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant

RBD

EC50 (nM)

EC50 confidence (nM)

Wuhan strain

40.7

1.8

Beta

35.2

1.7

Delta

33.6

2.2

Omicron

42.3

1.6