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Fig. 1 | BMC Medicine

Fig. 1

From: Organ-specific metastatic landscape dissects PD-(L)1 blockade efficacy in advanced non-small cell lung cancer: applicability from clinical trials to real-world practice

Fig. 1

Flowchart showing the design of the study. The double-arm OAK trial (atezolizumab versus docetaxel) was used as a discovery cohort to identify the prognostic and predictive effects of metastatic organs. A metastasis-based scoring system, termed METscore, was developed to forecast survival prospects of ICI therapy in the PD-L1-positvive population, and was further validated in PD-L1-selected atezolizumab trials (FIR and BIRCH) and a real-word ICI cohort. Abbreviations: NSCLC, non-small cell lung cancer; ICI, immune checkpoint inhibitor; PD-L1, programmed death-ligand 1; TC, tumor cell, IC: immune cell

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