Fig. 2
From: Diabetic kidney disease and risk of incident stroke among adults with type 2 diabetes
Hazard ratios for incident stroke by age group and CKD stage. Hazard ratios are adjusted for sex, race, treatment arm, duration of diabetes, hemoglobin A1C, cigarette smoking, alcohol intake; body mass index, total-to-HDL cholesterol, systolic BP, use of BP-lowering medications, atrial fibrillation and history of cardiovascular disease, use of antiplatelet agents (including aspirin)/ anticoagulants, diuretics, ACEI/ARB. CKD was classified according to the KDIGO clinical practice guidelines: (1) no CKD defined as eGFR ≥ 60 and UACR < 30; (2) CKD G1, as eGFR ≥ 90 and UACR ≥ 30; (3) CKD G2, as eGFR between 60 and 89 and UACR ≥ 30; (4) CKD G3, as eGFR between 30 and 59 regardless of UACR. ACEI indicates angiotensin-converting enzyme inhibitors; ARB, angiotensin-II receptor blockers; BP, blood pressure; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; KDIGO, Kidney Disease: Improving Global Outcomes; UACR, urine albumin-creatinine ratio