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Table 3 Rates and hazard ratios of incident stroke by combined measures of kidney function

From: Diabetic kidney disease and risk of incident stroke among adults with type 2 diabetes

Measures of kidney function No events/no at risk P-years Rate/1000 p-years Model 1 Model 2 Model 3
HR (95% CI) P HR (95% CI) P HR (95% CI) P
UACR eGFR          
< 30 ≥ 60 61/5703 27414.3 2.2 (1.7–2.9) 1 (reference)   1 (reference)   1 (reference)  
< 30 < 60 13/537 2698.0 4.8 (2.8–8.3) 1.76 (0.95–3.26) 0.070 1.64 (0.88–3.06) 0.117 1.59 (0.86–2.97) 0.142
  ≥ 30 ≥ 60 62/2508 11791.2 5.3 (4.1–6.7) 2.30 (1.61–3.28) < 0.001 1.80 (1.24–2.61) 0.002 1.79 (1.23–2.60) 0.002
  ≥ 30 < 60 20/422 2021.5 9.9 (6.4–15.3) 3.66 (2.17–6.17) < 0.001 2.61 (1.50–4.55) 0.001 2.54 (1.45–4.43) 0.001
  1. Model 1 adjusted for age, sex, race, and treatment arm; model 2, model 1 variables plus duration of diabetes, hemoglobin A1C, cigarette smoking, alcohol intake; body mass index, total-to-HDL cholesterol, systolic BP, use of BP-lowering medications, atrial fibrillation; history of CVD (excluding stroke) at baseline; model 3, model 2 variables plus use of antiplatelet agents (including aspirin)/ anticoagulants, diuretics, ACEI/ARB
  2. ACEI indicates angiotensin-converting enzyme inhibitors, ARB angiotensin-II receptor blockers, BP blood pressure, CI confidence interval, CVD cardiovascular disease, eGFR estimated glomerular filtration rate, HDL high-density lipoprotein, HR hazard ratio, p-years person-years, UACR urine albumin-creatinine ratio