Diabetic kidney disease and risk of incident stroke among adults with type 2 diabetes

Table 3 Rates and hazard ratios of incident stroke by combined measures of kidney function

Measures of kidney function		No events/no at risk	P-years	Rate/1000 p-years	Model 1		Model 2		Model 3
Measures of kidney function		No events/no at risk	P-years	Rate/1000 p-years	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
UACR	eGFR
< 30	≥ 60	61/5703	27414.3	2.2 (1.7–2.9)	1 (reference)		1 (reference)		1 (reference)
< 30	< 60	13/537	2698.0	4.8 (2.8–8.3)	1.76 (0.95–3.26)	0.070	1.64 (0.88–3.06)	0.117	1.59 (0.86–2.97)	0.142
≥ 30	≥ 60	62/2508	11791.2	5.3 (4.1–6.7)	2.30 (1.61–3.28)	< 0.001	1.80 (1.24–2.61)	0.002	1.79 (1.23–2.60)	0.002
≥ 30	< 60	20/422	2021.5	9.9 (6.4–15.3)	3.66 (2.17–6.17)	< 0.001	2.61 (1.50–4.55)	0.001	2.54 (1.45–4.43)	0.001

Model 1 adjusted for age, sex, race, and treatment arm; model 2, model 1 variables plus duration of diabetes, hemoglobin A_1C, cigarette smoking, alcohol intake; body mass index, total-to-HDL cholesterol, systolic BP, use of BP-lowering medications, atrial fibrillation; history of CVD (excluding stroke) at baseline; model 3, model 2 variables plus use of antiplatelet agents (including aspirin)/ anticoagulants, diuretics, ACEI/ARB
ACEI indicates angiotensin-converting enzyme inhibitors, ARB angiotensin-II receptor blockers, BP blood pressure, CI confidence interval, CVD cardiovascular disease, eGFR estimated glomerular filtration rate, HDL high-density lipoprotein, HR hazard ratio, p-years person-years, UACR urine albumin-creatinine ratio

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