Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort

Table 2 Spearman correlation coefficients between pre-diagnostic levels of inflammatory biomarkers and anthropometric factors among controls, adjusted for laboratory batch and age at blood donation

Biomarkers	Adiponectin	Leptin	L to A ratio	CRP	TNF-α	IFN-γ	IL-6	IL-8	IL-10	IL-1-RA	IL-17-D
Adiponectin	1
Leptin	− 0.18	1
L to A ratio	− 0.57	0.91	1
CRP	− 0.22	0.34	0.38	1
TNF-α	− 0.05	0.08	0.09	0.16	1
IFN-γ	− 0.02	− 0.01	0.01	0.13	0.37	1
IL-6	− 0.14	0.25	0.27	0.40	0.28	0.20	1
IL-8	0.03	− 0.03	− 0.04	− 0.01	0.32	0.12	0.18	1
IL-10	− 0.01	− 0.08	− 0.06	0.01	0.33	0.27	0.09	0.16	1
IL-1-RA	− 0.26	0.24	0.31	0.27	0.29	0.18	0.24	0.23	0.11	1
IL-17-D	0.11	− 0.05	− 0.08	− 0.07	0.07	− 0.01	0.01	0.06	0.07	− 0.02	1
BMI	− 0.25	0.60	0.61	0.40	0.14	0.03	0.31	0.02	− 0.03	0.34	− 0.07
Weight	− 0.23	0.55	0.55	0.35	0.12	0.02	0.27	− 0.01	− 0.02	0.31	− 0.07
Height	0.03	− 0.09	− 0.09	− 0.07	− 0.02	− 0.01	− 0.06	− 0.05	0.02	− 0.03	0.01
WC	− 0.29	0.53	0.57	0.35	0.15	0.05	0.28	0.01	− 0.01	0.33	− 0.06
HC	− 0.15	0.56	0.54	0.33	0.09	0.03	0.24	− 0.01	− 0.01	0.27	− 0.05
WHR	− 0.27	0.24	0.32	0.20	0.14	0.05	0.19	0.03	− 0.01	0.22	− 0.04

Abbreviations: BMI, body mass index; CRP, c-reactive protein; HC, hip circumference; IFN, interferon; IL, interleukin; L to A, leptin to adiponectin; SD, standard deviation; RA: receptor antagonist; TNF, tumour necrosis factor; WC, waist circumference; WHR, waist-to-hip ratio
Spearman correlation coefficients with P values <0.0001 are in bold

ISSN: 1741-7015