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Table 2 Number of cases, incidence rates of all-cause mortality, emergency department visits, and unscheduled hospitalizations after second dose of BNT162b2 and CoronaVac

From: Impact of a delayed second dose of mRNA vaccine (BNT162b2) and inactivated SARS-CoV-2 vaccine (CoronaVac) on risks of all-cause mortality, emergency department visit, and unscheduled hospitalization

Event

Before weighting

After weighting

Recommended (N = 654,900)

Delayed (N = 116,880)

Delayed vs recommended interval

Cumulative incidence

Crude incidence rate (events/10,000 person-days)

Cumulative incidence

Crude incidence rate (events/10,000 person-days)

HRa

95% CI

P-value

Cases with event

Rate

Estimate

95% CI

Person-days

Cases with event

Rate

Estimate

95% CI

Person-days

Mortality after second dose

  BNT162b2

15

0.0037%

0.0133

(0.01, 0.02)

11,241,070

2

0.0125%

0.0446

(0.01, 0.16)

448,656

4.438

(0.951, 20.701)

0.058

  CoronaVac

16

0.0063%

0.0225

(0.01, 0.04)

7,095,767

7

0.0069%

0.0248

(0.01, 0.05)

2,823,889

1.185

(0.478, 2.937)

0.714

ED visit after second dose

  BNT162b2

13,818

3.44%

12.55

(12.34, 12.76)

11,011,002

635

3.96%

14.49

(13.38, 15.66)

438,314

1.037

(0.951, 1.130)

0.411

  CoronaVac

7856

3.10%

11.26

(11.01, 11.51)

6,977,752

3112

3.09%

11.21

(10.82, 11.61)

2,776,922

0.966

(0.926, 1.008)

0.113

Unscheduled hospitalization after second dose

  BNT162b2

2929

0.73%

2.62

(2.52, 2.71)

11,195,142

124

0.77%

2.78

(2.31, 3.31)

446,704

1.054

(0.867, 1.281)

0.597

  CoronaVac

2068

0.82%

2.93

(2.80, 3.06)

7,065,542

781

0.77%

2.78

(2.59, 2.98)

2,812,393

0.956

(0.878, 1.040)

0.294

  1. HR Hazard ratio, CI Confidence interval, ED Emergency department
  2. aHR > 1 (or < 1) indicates persons delaying the second dose had a higher risk (or lower risk) of outcome events after the second dose, compared to persons receiving the second dose within the recommended interval