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Fig. 3 | BMC Medicine

Fig. 3

From: Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis

Fig. 3

DAG demonstrating the proposed causal interactions of BMI, SHBG, fasting insulin and bioavailable testosterone on endometrial cancer (overall and the endometrioid histological subtype). DAG = directed acyclic diagram, BMI = body mass index, SHBG = sex hormone-binding globulin. Red lines indicate a negative causal effect, green lines indicate a positive causal effect

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