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Table 3 Results of MR analyses examining effect of risk factors on endometrial cancer risk

From: Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis

Exposure

Outcome

Method

OR (95% CI)

P value

LDL cholesterol

Overall endometrial cancer

IVW

0.95 (0.87 to 1.04)

3.05 × 10−1

Weighted median

0.92 (0.82 to 1.03)

1.31 × 10−1

Weighted mode

0.91 (0.82 to 1.02)

9.54 × 10−2

MR-Egger

0.90 (0.79 to 1.03)

1.35 × 10−1

Endometrioid endometrial cancer

IVW

0.98 (0.89 to 1.08)

6.70 × 10−1

Weighted median

0.96 (0.84 to 1.10)

5.61 × 10−1

Weighted mode

0.93 (0.83 to 1.06)

2.79 × 10−1

MR-Egger

0.93 (0.81 to 1.07)

3.31 × 10−1

HDL cholesterol

Overall endometrial cancer

IVW

1.09 (0.97 to 1.23)

1.48 × 10−1

Weighted median

1.10 (0.96 to 1.26)

1.89 × 10−1

Weighted mode

1.07 (0.94 to 1.23)

3.11 × 10−1

MR-Egger

1.08 (0.86 to 1.35)

4.99 × 10−1

Endometrioid endometrial cancer

IVW

1.04 (0.90 to 1.19)

6.05 × 10−1

Weighted median

0.99 (0.84 to 1.16)

8.76 × 10−1

Weighted mode

1.03 (0.88 to 1.21)

7.23 × 10−1

MR-Egger

0.92 (0.71 to 1.20)

5.61 × 10−1

Triglyceride

Overall endometrial cancer

IVW

0.95 (0.84 to 1.06)

3.55 × 10−1

Weighted median

0.87 (0.75 to 1.01)

7.75 × 10−2

Weighted mode

0.91 (0.79 to 1.04)

1.61 × 10−1

MR-Egger

0.83 (0.69 to 1.00)

6.03 × 10−2

Endometrioid endometrial cancer

IVW

0.95 (0.83 to 1.09)

4.65 × 10−1

Weighted median

0.92 (0.78 to 1.08)

3.21 × 10−1

Weighted mode

0.91 (0.77 to 1.08)

2.87 × 10−1

MR-Egger

0.87 (0.70 to 1.07)

2.02 × 10−1

Total serum cholesterol

Overall endometrial cancer

IVW

0.90 (0.81 to 1.00)

4.01 × 10−2

Weighted median

0.80 (0.71 to 0.90)

2.08 × 10−4

Weighted mode

0.82 (0.73 to 0.91)

5.97 × 10−4

MR-Egger

0.84 (0.71 to 0.98)

3.09 × 10−2

Endometrioid endometrial cancer

IVW

0.91 (0.82 to 1.02)

9.31 × 10−2

Weighted median

0.81 (0.71 to 0.93)

3.40 × 10−3

Weighted mode

0.84 (0.74 to 0.97)

1.64 × 10−2

MR-Egger

0.86 (0.72 to 1.01)

7.60 × 10−2

Glucose

Overall endometrial cancer

IVW

0.95 (0.79 to 1.14)

5.64 × 10−1

Weighted median

0.97 (0.80 to 1.17)

7.36 × 10−1

Weighted mode

0.93 (0.78 to 1.11)

4.47 × 10−1

MR-Egger

0.99 (0.73 to 1.34)

9.29 × 10−1

Endometrioid endometrial cancer

IVW

0.90 (0.73 to 1.11)

3.26 × 10−1

Weighted median

0.98 (0.77 to 1.23)

8.31 × 10−1

Weighted mode

0.98 (0.80 to 1.20)

8.29 × 10−1

MR-Egger

0.94 (0.67 to 1.33)

7.39 × 10−1

Fasting insulin

Overall endometrial cancer

IVW

3.93 (2.29 to 6.74)

7.18 × 10−7

Weighted median

3.49 (1.60 to 7.62)

1.67 × 10−3

Weighted mode

3.55 (0.85 to 14.78)

1.06 × 10−1

MR-Egger

8.28 (0.67 to 102.10)

1.25 × 10−1

Endometrioid endometrial cancer

IVW

4.64 (2.30 to 9.36)

1.84 × 10−5

Weighted median

3.93 (1.56 to 9.93)

3.80 × 10−3

Weighted mode

3.28 (0.69 to 15.62)

1.61 × 10−1

MR-Egger

21.59 (0.78 to 593.93)

9.66 × 10−2

IGF-1 (cis and trans variants)

Overall endometrial cancer

IVW

0.93 (0.85 to 1.06)

2.60 × 10−1

Weighted median

1.01 (0.85 to 1.20)

8.96 × 10−1

Weighted mode

1.22 (0.89 to 1.67)

2.28 × 10−1

MR-Egger

1.17 (0.85 to 1.60)

3.49 × 10−1

Endometrioid endometrial cancer

IVW

0.89 (0.77 to 1.03)

1.12 × 10−1

Weighted median

1.03 (0.84 to 1.25)

8.06 × 10−1

Weighted mode

1.32 (0.92 to 1.90)

1.30 × 10−1

MR-Egger

1.22 (0.85 to 1.76)

2.75 × 10−1

IGF-1 (cis variants)

Overall endometrial cancer

Wald ratio

1.20 (0.79 to 1.82)

3.92 × 10−1

Endometrioid endometrial cancer

Wald ratio

1.40 (0.85 to 2.28)

1.84 × 10−1

IL-6 (scaled to natural log transformed mg/L change in CRP)

Overall endometrial cancer

IVW

0.90 (0.66 to 1.21)

4.80 × 10−1

Endometrioid endometrial cancer

IVW

0.86 (0.60 to 1.23)

4.01 × 10−1

Adiponectin (cis and trans variants)

Overall endometrial cancer

IVW

0.92 (0.79 to 1.08)

3.17 × 10−1

Endometrioid endometrial cancer

IVW

0.94 (0.78 to 1.13)

4.99 × 10−1

Adiponectin (cis variants)

Overall endometrial cancer

IVW

0.95 (0.83 to 1.08)

3.94 × 10−1

Endometrioid endometrial cancer

IVW

1.00 (0.86 to 1.16)

9.92 × 10−1

Leptin

Overall endometrial cancer

Wald Ratio

1.03 (0.68 to 1.54)

8.96 × 10−1

Endometrioid endometrial cancer

Wald Ratio

0.88 (0.54 to 1.42)

5.99 × 10−1

CRP (cis and trans variants)

Overall endometrial cancer

IVW

1.07 (0.94 to 1.22)

3.03 × 10−1

Weighted median

0.97 (0.84 to 1.12)

6.76 × 10−1

Weighted mode

1.02 (0.91 to 1.14)

7.80 × 10−1

MR-Egger

0.96 (0.80 to 1.16)

6.99 × 10−1

Endometrioid endometrial cancer

IVW

1.12 (0.96 to 1.30)

1.39 × 10−1

Weighted median

1.03 (0.87 to 1.23)

6.92 × 10−1

Weighted mode

1.04 (0.90 to 1.20)

6.34 × 10−1

MR-Egger

0.97 (0.78 to 1.20)

7.69 × 10−1

CRP (cis variants)

Overall endometrial cancer

IVW

0.98 (0.85 to 1.13)

7.52 × 10−1

Endometrioid endometrial cancer

IVW

0.98 (0.83 to 1.16)

8.02 × 10−1

Total testosterone

Overall endometrial cancer

IVW

1.64 (1.43 to 1.88)

1.71 × 10−12

Weighted median

1.67 (1.39 to 2.01)

3.95 × 10−8

Weighted mode

1.74 (1.38 to 2.20)

8.33 × 10−6

MR-Egger

1.81 (1.38 to 2.38)

4.17 × 10−5

Endometrioid endometrial cancer

IVW

1.60 (1.36 to 1.87)

8.70 × 10−9

Weighted median

1.81 (1.45 to 2.26)

2.05 × 10−7

Weighted mode

1.88 (1.42 to 2.48)

2.34 × 10−5

MR-Egger

1.74 (1.26 to 2.41)

1.02 × 10−3

Bioavailable testosterone

Overall endometrial cancer

IVW

1.46 (1.29 to 1.65)

3.48 × 10−9

Weighted median

1.47 (1.20 to 1.82)

2.46 × 10−4

Weighted mode

1.51 (1.19 to 1.93)

1.16 × 10−3

MR-Egger

1.90 (1.46 to 2.47)

5.63 × 10−6

Endometrioid endometrial cancer

IVW

1.46 (1.26 to 1.69)

3.08 × 10−7

Weighted median

1.42 (1.14 to 1.76)

1.97 × 10−3

Weighted mode

1.60 (1.20 to 2.13)

1.59 × 10−3

MR-Egger

1.79 (1.31 to 2.43)

3.08 × 10−7

SHBG

Overall endometrial cancer

IVW

0.71 (0.59 to 0.85)

2.07 × 10−4

Weighted median

0.64 (0.48 to 0.86)

2.54 × 10−3

Weighted mode

0.69 (0.53 to 0.89)

4.97 × 10−3

MR-Egger

0.62 (0.46 to 0.84)

2.52 × 10−3

Endometrioid endometrial cancer

IVW

0.65 (0.54 to 0.80)

3.31 × 10−5

Weighted median

0.60 (0.43 to 0.86)

4.90 × 10−3

Weighted mode

0.58 (0.40 to 0.82)

2.50 × 10−3

MR-Egger

0.61 (0.44 to 0.84)

3.33 × 10−3

  1. ORs are shown per increase in inverse-normal transformed nmol/L SHBG, natural log transformed pmol/L fasting insulin, inverse-normal transformed nmol/L total testosterone, natural log transformed nmol/L bioavailable testosterone, SD (38.7 mg/dL) LDL cholesterol, nmol/L IGF-1, mmol/L blood glucose, natural log transformed CRP mg/L IL-6, natural log transformed μg/ml adiponectin for combined instrument, natural log transformed μg/ml cis-only adiponectin, natural log transformed mg/L CRP, mg/dL triglyceride, SD (41.7 mg/dL) total serum cholesterol, mg/dL HDL cholesterol, pg/mL leptin. LDL low-density lipoprotein, HDL high-density lipoprotein, IGF-1 insulin-like growth factor-1, IL-6 interleukin-6, CRP C-reactive protein, SHBG sex hormone-binding globulin, IVW inverse-variance weighted. For instrument construction of IGF-1 (cis and trans variants), a P value of 5 × 10−6 was used
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BMC Medicine

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