Table 4 Results of MR analyses examining the effect of BMI on molecular risk factors
Outcome | Method | Effect estimate (95% CI) | P value |
|---|---|---|---|
Total serum cholesterol | IVW | − 0.03 (− 0.06 to 0.01) | 1.22 × 10−1 |
Weighted median | − 0.06 (− 0.11 to − 0.01) | 2.98 × 10−2 | |
Weighted mode | − 0.08 (− 0.15 to 0.00) | 4.46 × 10−2 | |
MR-Egger | − 0.08 (− 0.16 to 0.00) | 3.89 × 10−2 | |
Fasting insulin | IVW | 0.17 (0.15 to 0.19) | 1.51 × 10−74 |
Weighted median | 0.18 (0.15 to 0.21) | 8.51 × 10−31 | |
Weighted mode | 0.18 (0.12 to 0.24) | 1.88 × 10−9 | |
MR-Egger | 0.20 (0.16 to 0.25) | 1.30 × 10−16 | |
Total testosterone | IVW | 0.08 (0.05 to 0.11) | 9.04 × 10−10 |
Weighted median | 0.06 (0.03 to 0.09) | 4.95 × 10−4 | |
Weighted mode | − 0.01 (− 0.08 to 0.07) | 8.60 × 10−1 | |
MR-Egger | 0.02 (− 0.05 to 0.09) | 5.23 × 10−1 | |
Bioavailable testosterone | IVW | 0.26 (0.23 to 0.29) | 9.97 × 10−68 |
Weighted median | 0.24 (0.20 to 0.28) | 1.72 × 10−38 | |
Weighted mode | 0.09 (0.01 to 0.17) | 2.41 × 10−2 | |
MR-Egger | 0.16 (0.08 to 0.24) | 4.36 × 10−5 | |
SHBG | IVW | − 0.17 (− 0.19 to − 0.16) | 4.86 × 10−125 |
Weighted median | − 0.16 (− 0.18 to − 0.15) | 8.85 × 10−77 | |
Weighted mode | − 0.15 (− 0.18 to − 0.12) | 8.43 × 10−20 | |
MR-Egger | − 0.13 (− 0.17 to − 0.09) | 3.11 × 10−11 |