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Fig. 6 | BMC Medicine

Fig. 6

From: The association of neurodevelopmental abnormalities, congenital heart and renal defects in a tuberous sclerosis complex patient cohort

Fig. 6

The frequency and co-occurrence of TSC manifestations and lifetime trajectory of organ involvement between CHD, NDD and KD in TSC1 and TSC2 patients. A Lifetime prevalence and degree of co-morbidity between CHD, NDD and KD in all patients combined, TSC1 patients and TSC2 patients. The size of circles is the proportional to the prevalence of each organ manifestation labelled in brackets, and the width of connecting lines is proportional to the degree of relative comorbidity between disorders; B The probability trajectory of lifetime organ involvement in TSC1 patients from point of initial presentation. Initial presentation at the base of the tree occurs in either the heart, brain or kidney and branches to other organs as indicated by transition probability on a branch; C The probability trajectory of lifetime organ involvement in TSC2 patients from point of initial presentation. CHD, congenital heart disorder; NDD, neurodevelopmental disorder; RD, renal disease

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