Fig. 5

Association between NMP and response to ICI in dMMR/MSI-H G/GEJ adenocarcinomas. A Basic clinicopathological characteristics and mutations of the PI3K-AKT-mTOR pathway of the ICI treatment cohort. B, C Association of NMP with tumor mutational burden (B) and PD-L1 CPS score (C). D Bar plot illustrating best response and ROC curve of the NMP to predict ORR. The NMP of each patient is labeled with red (NMP, 0), blue (NMP, 1), and green (NMP > 1). E, F Kaplan-Meier curves of PFS (E) and OS (F) in the NMP-low (0/1) and NMP-high (> 1) patients. G Subgroup analysis of PFS. H Association between NMP and DTICs. I. Representative images of DTICs. Abbreviations: AUC, area under curve; CI, confidence interval; CPS, combined positive score; CR, complete response; DTIC, density of tumor-infiltrating immune cells; ECOG, Eastern Cooperative Oncology Group; HR, hazard ratio; NA, not applicable; ORR, objective response rate; OS, overall survival; PD, progressive disease; PD-L1, programmed death-ligand 1; PFS, progression-free survival; PR, partial response; SD, stable disease; WT, wildtype