Fig. 4

Proportion of breast cancer patients from the validation dataset identified as being at high risk. The prospective cohort of healthy women—the Singapore Chinese Health Study [SCHS]—was used for validation. Criteria for high-risk: (1) at least one first degree relative diagnosed with breast or ovarian cancer [FH], (2) 5-year absolute risk above 1.3% estimated by the polygenic risk score [PRS], and (3) 5-year absolute risk above 1.3% estimated by Gail risk model [Gail]. PRS is standardized with mean and standard deviation of Chinese controls from the Singapore and Malaysia dataset. *Note: This plot uses age at recruitment; breast cancer may not occur within 5 years of recruitment