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Table 2 Sensitivity analyses. Multivariable-adjusted hazard ratios (95 % CI) for prostate cancer death in relation to adiposity measurements at recruitment in 218,237 men from UK Biobank

From: Adiposity and risk of prostate cancer death: a prospective analysis in UK Biobank and meta-analysis of published studies

  BMI Body fat percentage Waist circumference Waist to hip ratio
n prostate cancer deaths Per 5 kg/m2 increase p-trend1 n cases Per 5 % increase p-trend1 n cases Per 10 cm increase p-trend1 n cases Per 0.05 unit increase p-trend1
Overall 659 1.07 (0.97–1.17) 0.190 645 1.00 (0.94–1.08) 0.892 659 1.06 (0.99–1.14) 0.116 659 1.07 (1.01–1.14) 0.028
Excluding first 5 years of follow-up 568 1.06 (0.96–1.18) 0.265 559 1.01 (0.93–1.09) 0.802 568 1.05 (0.98–1.14) 0.180 568 1.07 (1.00–1.14) 0.060
Excluding men with BMI ≥ 25 kg/m2, per 1 SD increment 144 0.93 (0.79–1.10) 0.404 140 0.87 (0.74–1.03) 0.118 144 1.04 (0.87–1.24) 0.667 144 1.13 (0.96–1.33) 0.144
Excluding extreme values: percentiles 1–99 659 1.07 (0.97–1.18) 0.170 645 1.01 (0.94–1.08) 0.826 659 1.06 (0.99–1.14) 0.101 659 1.07 (1.01–1.14) 0.023
Excluding men < 50 years of age 650 1.06 (0.96–1.17) 0.223 636 1.00 (0.93–1.08) 0.950 650 1.06 (0.98–1.14) 0.137 650 1.07 (1.01–1.14) 0.034
Per 1 SD increment 659 1.06 (0.98–1.15) 0.170 645 1.01 (0.93–1.10) 0.826 659 1.07 (0.99–1.16) 0.101 659 1.10 (1.01–1.19) 0.023
Residualsa        659 1.08 (0.92–1.27) 0.325 659 1.07 (0.99–1.15) 0.072
  1. Abbreviations: BMI body mass index
  2. Cox regression analyses. All models are stratified by region and age at recruitment and adjusted for age (underlying time variable), Townsend deprivation score, ethnicity, lives with a wife or partner, smoking, physical activity, alcohol consumption, height, diabetes, and history of PSA test. Full details for each covariate are provided in the statistical section
  3. 1P-values for trend are obtained by entering the anthropometric variable per increment in the Cox regression model
  4. aHR (95% CI) is from the multiple adjusted model (above) after accounting for the residuals of waist circumference and waist to hip ratio regressed on BMI for analyses of waist circumference and waist to hip ratio as exposures