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Table 6 Adverse effects

From: Prophylactic NAC promoted hematopoietic reconstitution by improving endothelial cells after haploidentical HSCT: a phase 3, open-label randomized trial

 

NAC group A (N=80)

High-risk control group B (N=40)

Grades 1–2

Grade 3

Grade 4

Grade 5

Grades 1–2

Grade 3

Grade 4

Grade 5

Skina

25(31)

0

0

0

8(20)

0

0

0

Gastrointestinala

54(67)

16(20)

0

0

30(70)

7(18)

0

0

Hepatobiliary/pancreatica

14(17)

5(6)

0

0

5(13)

1(3)

0

0

Cardiac

12(15)

1(1)

0

0

7(18)

0

0

0

Renal/genitourinary

8(10)

0

0

0

6(15)

0

0

0

Infectionsb

5(6)

16(20)

0

3(4)

2(5)

8(20)

1(3)

1(3)

Nervous system disorders

2(3)

0

0

0

1(3)

0

0

0

  1. Grade 1–2 adverse events in more than 10 of patients and all grade 3–5 adverse events were recorded from enrollment to 60 days post-transplantation
  2. aExcluded the patients with GVHD
  3. bExcluded the patients with cytomegalovirusviremia and Epstein-Barr virus viremia