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Table 7 Liver enzymes and bilirubin

From: Prophylactic NAC promoted hematopoietic reconstitution by improving endothelial cells after haploidentical HSCT: a phase 3, open-label randomized trial

Parameters Alanine aminotransferase (ALT)
Median (range), U/l
Aspartate aminotransferase (AST)
Median (range), U/l
Bilirubin
Median (range), μmol/l
NAC group A (N=80) High-risk Control group B (N=40) NAC group A (N=80) High-risk Control group B (N=40) NAC group A (N=80) High-risk Control group B (N=40)
Before busulfan 19.5 (2.0–152.0) 22.0 (5.0–82.0) 18.0 (9.0–75.0) 19.5 (9.0–40.0) 9.7 (3.2–30.8) 10.5 (4.4–22.7)
After busulfan 15.5 (4.0–151.0) 19.5 (6.0–91.0) 17.0 (11.0–83.0) 17.0 (10.0–43.0) 9.5 (4.0–33.1) 9.8 (4.6–19.0)
Day 21 post transplant 34.5 (7.0–926.0) 33.0 (8.0–300.0) 25.0 (11.0–317.0) 27.0 (8.0–158.0) 10.7 (4.0–27.1) 12.1 (3.8–20.2)
Day 60 post transplant 19.0 (4.0–254.0) 22.0 (8.0–156.0) 23.0 (10.0–312.0) 25.0 (14.0–76.0) 11.6 (6.4–116.7) 11.8 (6.3–41.1)
  1. Abbreviations: NAC N-acetyl-L-cysteine, AST aspartate aminotransferase (normal range <40U/l), ALT alanine aminotransferase (normal range <40U/l), bilirubin (normal range <26μmol/l)