Prophylactic NAC promoted hematopoietic reconstitution by improving endothelial cells after haploidentical HSCT: a phase 3, open-label randomized trial

Table 7 Liver enzymes and bilirubin

Parameters	Alanine aminotransferase (ALT) Median (range), U/l		Aspartate aminotransferase (AST) Median (range), U/l		Bilirubin Median (range), μmol/l
Parameters	NAC group A (N=80)	High-risk Control group B (N=40)	NAC group A (N=80)	High-risk Control group B (N=40)	NAC group A (N=80)	High-risk Control group B (N=40)
Before busulfan	19.5 (2.0–152.0)	22.0 (5.0–82.0)	18.0 (9.0–75.0)	19.5 (9.0–40.0)	9.7 (3.2–30.8)	10.5 (4.4–22.7)
After busulfan	15.5 (4.0–151.0)	19.5 (6.0–91.0)	17.0 (11.0–83.0)	17.0 (10.0–43.0)	9.5 (4.0–33.1)	9.8 (4.6–19.0)
Day 21 post transplant	34.5 (7.0–926.0)	33.0 (8.0–300.0)	25.0 (11.0–317.0)	27.0 (8.0–158.0)	10.7 (4.0–27.1)	12.1 (3.8–20.2)
Day 60 post transplant	19.0 (4.0–254.0)	22.0 (8.0–156.0)	23.0 (10.0–312.0)	25.0 (14.0–76.0)	11.6 (6.4–116.7)	11.8 (6.3–41.1)

Abbreviations: NAC N-acetyl-L-cysteine, AST aspartate aminotransferase (normal range <40U/l), ALT alanine aminotransferase (normal range <40U/l), bilirubin (normal range <26μmol/l)

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