Fig. 5
From: Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth
Crystal structure of human AAT bound to cattle trypsin (PDB code 1OPH, [46]). Structure is drawn as ribbons, and AAT and trypsin are colored in pink and cyan, respectively. The region of AAT that interacts with trypsin is highlighted in red; this region is known as the reactive center loop [45]. Variants of SERPINA1 identified via whole exome sequencing of preterm birth cases (this study) cause amino acid changes Arg247Cys (R247C), Glu366Lys (E366K, Z variant), and Glu387Lys (E387K, F variant) in AAT. Figure prepared with PyMOL