Table 3 Proteomic changes between chorionic (Ch) and basal (Ba) plates of human placenta in spontaneous term (T) and preterm (P) birth
From: Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth
Spot | Protein | UniProt-KB | Description | Theoretical pI/MW (kDa) | Detected pI/MW (kDa) | Ratio | |
|---|---|---|---|---|---|---|---|
Ch vs Ba | |||||||
T | P | ||||||
Basal plate (Ba) vs chorionic plate (Ch) | |||||||
 25 | AAT | P01009 | α-1-antitrypsin (isoform 1) | 5.37 47 (5.37 44) | 4.85 61 | (− 1.32) | − 1.62 |
 19 | ALB | P02768 | Serum albumin (isoform 1) | 5.92 69 (5.67 67) | 5.76 65 | (− 1.16) | − 1.54 |
 20 | ALB | P02768 | Serum albumin (isoform 1) |  | 5.82 66 | (− 1.13) | − 1.53 |
 63 | ANXA3 | P12429 | Annexin A3 | 5.62 36 (5.63 36) | 5.58 31 | − 2.83 | − 1.72 |
 67 | APCS | P02743 | Serum amyloid P-component | 6.10 25 (6.12 25) | 5.52 25 | − 2.75 | − 1.86 |
 74 | APOA1 | P02647 | Apolipoprotein A-I | 5.56 31 (5.27 28) | 5.18 22 | (− 1.67) | − 1.64 |
 7 | CFB | P00751 | Complement factor B (isoform1) | 6.67 86 (6.66 83) | 5.95 110 | (− 1.36) | − 1.86 |
 81 | CFL1 | P23528 | Cofilin-1 | 8.22 19 (8.26 18) | 6.01 19 | (− 1.32) | − 1.89 |
 58 | CLU | P10909 | Clusterin (isoform 3) | 6.19 32 | 4.76 36 | − 2.87 | (− 1.84) |
 59 | CLU | P10909 | Clusterin (isoform 3) | 4.82 35 | − 2.98 | (− 1.75) | |
 60 | CLU | P10909 | Clusterin (isoform 3) | 4.88 34 | − 3.69 | − 1.80 | |
 9 | EEF2 | P13639 | Elongation factor 2 | 6.41 95 (6.42 95) | 6.42 95 | 2.32 | 1.71 |
 48* | FGB | P02675 | Fibrinogen ß chain (C-terminal fragment) | 8.54 56 (7.95 51) | 5.51 38 | − 2.45 | (− 1.23) |
 49* | FGB | P02675 | Fibrinogen ß chain (C-terminal fragment) | 5.60 39 | − 3.17 | (− 1.46) | |
 50* | FGB | P02675 | Fibrinogen ß chain (C-terminal fragment) | 5.71 39 | − 3.42 | (− 1.74) | |
 78 | FTL | P02792 | Ferritin light chain | 5.50 20 (5.50 20) | 5.50 20 | 2.75 | (− 1.28) |
 8 | GSN | P06396 | Gelsolin (isoform 1) | 5.90 86 (5.72 83) | 5.82 95 | − 2.59 | − 2.39 |
 28 | HNRNPK | P61978 | Heterogeneous nuclear ribonucleoprotein K (isoform 1-3) | 5.39 51 | 5.39 57 | 2.45 | 1.64 |
 1 | ITIH4 | Q14624 | Inter-α-trypsin inhibitor heavy chain H4 (isoform 1) | 6.51 103 (6.11 100) | 4.90 137 | (− 1.29) | − 1.91 |
 2 | ITIH4 | Q14624 | Inter-α-trypsin inhibitor heavy chain H4 (isoform 1) | 4.92 136 | (− 1.22) | − 2.01 | |
 3 | ITIH4 | Q14624 | Inter-α-trypsin inhibitor heavy chain H4 (isoform 1) | 4.94 135 | (− 1.38) | − 2.25 | |
 43 | KRT19 | P08727 | Keratin, type I cytoskeletal 19 | 5.05 44 | 4.85 41 | (− 1.48) | − 1.85 |
 44 | KRT19 | P08727 | Keratin, type I cytoskeletal 19 | 4.87 41 | (− 1.53) | − 1.79 | |
 45 | KRT19 | P08727 | Keratin, type I cytoskeletal 19 | 4.90 41 | (− 1.25) | − 1.74 | |
 46 | KRT19 | P08727 | Keratin, type I cytoskeletal 19 | 4.93 41 | (− 1.35) | − 1.57 | |
 33 | LUM | P51884 | Lumican | 6.16 38 (6.17 37) | 4.45 53 | − 5.02 | − 9.67 |
 34 | LUM | P51884 | Lumican | 4.51 53 | − 4.52 | − 7.79 | |
 35 | LUM | P51884 | Lumican | 4.61 53 | − 7.59 | − 9.41 | |
 36 | LUM | P51884 | Lumican | 4.71 52 | − 5.23 | − 5.48 | |
 37 | LUM | P51884 | Lumican | 4.72 52 | (− 2.79) | − 2.96 | |
 88 | S100A6 | P06703 | Protein S100-A6 | 5.32 10 | 4.95 10 | (1.12) | − 2.39 |
 61 | TPM1 | P09493 | Tropomyosin α-1 chain (isoform 2,3,4) | 4.77 27 | 4.71 33 | − 3.03 | − 1.99 |
 62 | TPM1 | P09493 | Tropomyosin α-1 chain (isoform 1) | 4.69 33 | 4.69 33 | − 2.90 | − 1.89 |
 55 | TPM2 | P07951 | Tropomyosin ß chain (isoform 2) | 4.63 33 | 4.62 35 | − 3.91 | − 2.75 |
 29 | WARS | P23381 | Tryptophan-tRNA ligase, cytoplasmic (isoform 1) | 5.83 53 (5.83 53) | 5.83 55 | 2.29 | 2.05 |
 24 | – | – | – | – | 5.53 56 | (1.80) | 1.88 |
 87 | – | – | – | – | 4.74 13 | (− 1.10) | − 2.17 |