Table 1 Baseline clinical characteristics of the male study population
|
Mild-moderate N=114 |
Severe-recovered N=97 |
Severe-deceased N=38 | p-value1–2 | p-value1-3 | p-value2–3 | |
|---|---|---|---|---|---|---|
| Age (years), median (IQR) | 59 (56–63) | 56 (53–59) | 68 (67–71) | 0.1096 | 0.0001 | <0.0001 |
| Length of stay (days), median (IQR) | 8 (7–9) | 30.5 (27–34) | 19 (9–26) | <0.0001 | <0.0001 | 0.0009 |
| Comorbidity, n° (%) | 54 (47.36) | 57 (58.76) | 28 (73.68) | 0.1279 | 0.0051 | 0.1175 |
| Hypertension | 35 (30.70) | 31 (31.96) | 21 (55.26) | 0.8822 | 0.0109 | 0.0178 |
| Diabetes | 20 (17.54) | 15 (16.46) | 11 (28.95) | 0.7143 | 0.1630 | 0.0908 |
| Cancer | 6 (5.26) | 3 (3.09) | 3 (7.89) | 0.5115 | 0.6915 | 0.3497 |
| Cardiovascular diseases | 9 (7.89) | 12 (12.37) | 3 (7.89) | 0.3573 | 0.9999 | 0.5560 |
| Chronic Lung diseases | 10 (8.77) | 6 (6.19) | 5 (13.16) | 0.6046 | 0.5297 | 0.2912 |
| Obesity-Dyslipidaemia | 16 (14.03) | 33 (34.02) | 11 (28.95) | 0.0009 | 0.0497 | 0.6842 |
| Chronic Kidney disease | 6 (5.26) | 2 (2.06) | 1 (2.63) | 0.2927 | 0.6808 | 0.6727 |
| Others | 9 (7.89) | 13 (13.4) | 7 (18.42) | 0.2586 | 0.1220 | 0.5903 |
| Biochemical parameters, median (IQR) | ||||||
| Testosterone | 144.3 (112.3–189.3) | 52.91 (45.03–66.73) | 58.48 (46.83–81.94) | <0.0001 | <0.0001 | 0.9999 |
| Leucocytes n° | 6.32 (5.78–6.88) | 7.80 (6.83–8.80) | 8.70 (7.20–9.65) | <0.0001 | 0.0051 | 0.9999 |
| Lymphocytes n° | 1.20 (1.0–1.4) | 0.77 (0.70–0.82) | 0.8 (0.65–0.90) | <0.0001 | 0.0001 | 0.9999 |
| Lymphocytes % | 18.55 (16.15–1.57) | 9.20 (8.18–11.28) | 10.89 (7.95–13.38) | <0.0001 | <0.0001 | 0.9999 |
| Neutrophils | 4.57 (3.92–4.90) | 6.26 (5.53–7.38) | 6.39 (5.53–8.34) | <0.0001 | 0.0007 | 0.9999 |
| Interleukine-6 | 42.30 (25.33–53.46) | 130.8 (112.10–160.6) | 215.30 (117.6–996.4) | <0.0001 | <0.0001 | 0.9999 |
| C-reactive protein | 9.57 (6.76–10.88) | 17.47 (12.17–0.72) | 14.56 (9.84–24.019) | <0.0001 | 0.0069 | 0.9999 |
| LDH | 324 (296.0–369.0) | 472.5 (440.0–506.0) | 493.0 (429.0–583.0) | <0.0001 | <0.0001 | 0.9999 |
| D-Dimer | 236 (213.0–311.0) | 529.0 (361.0–711.0) | 421.5 (260.0–684.0) | <0.0001 | 0.0210 | 0.9999 |
| Ferritin | 934 (679.0–1089.0) | 1289 (1100.0–1574.0) | 1443.0 (554.9–1919.0) | 0.0022 | 0.7403 | 0.6783 |