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Fig. 2 | BMC Medicine

Fig. 2

From: Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway

Fig. 2

Exogenous BHB supplement alleviates DSS-induced colitis. ag Littermate WT mice (n = 7 to 10 per group) were fed with drinking water for 6 days, then 2.5% DSS in drinking water for 5 days, and followed by drinking water for 6 days, or with drinking water alone for 17 days. These mice were rectally injected with BHB enema or saline as a control. b, c Body weight changes and disease activity index were monitored daily after DSS administration. d Representative images of the colons from BHB-treated mice and controls. e Mice were killed on day 18, and colon lengths were measured. f, g Colon sections were examined histologically. f Histology scores for colonic inflammation were measured. g Representative images of the H&E-stained colon sections of different treatment groups (scale bars: 150 μm). b, c, e, f Data represent means ± SEM; *P< 0.05, **P< 0.01 by unpaired Student’s t test. Data shown are representative of three independent experiments

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