Fig. 1

Associations of metabolic biomarkers with risk of incident type 2 diabetes among 50,519 participants in the association analyses population. Hazard ratios (with 95% confidence intervals) are presented per 1−SD higher metabolic biomarker on the natural log scale, stratified by age-at-risk and sex and adjusted for assessment centre, Townsend Deprivation Index, ethnicity, parental history of diabetes, smoking, alcohol drinking, physical activity, dietary factors (whole and refined grains, fruit, vegetables, cheese, unprocessed red meat, processed meat, non-oily and oily fish, type of spread, caffeinated and decaffeinated coffee, tea and dietary supplements), body mass index, waist-to-hip ratio, fasting duration and spectrometer. *False discovery rate controlled p < 0.01. Apo-A1, apolipoprotein A1; Apo-B, apolipoprotein B; DHA, docosahexaenoic acid; FA, fatty acids; FAw3, omega-3 fatty acids; FAw6, omega-6 fatty acids; HDL, high-density lipoproteins; HDL-D, high-density lipoprotein particle diameter; IDL, intermediate-density lipoproteins; L, large; LA, linoleic acid; LDL, low-density lipoproteins; LDL-D, low-density lipoprotein particle diameter; LP, lipoprotein; M, medium; MUFA, monounsaturated fatty acids; PUFA, polyunsaturated fatty acids; S, small; SFA, saturated fatty acids; T2D, type 2 diabetes; VLDL, very low-density lipoproteins; VLDL-D, very low-density lipoprotein particle diameter; XL, very large; XS, very small; XXL, extremely large