Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections

Table 3 Overview of the most relevant human genes obtained from the analysis of host-pathogen gene-gene association networks

Gene	Name	NSTI type	Description	Reference
ZFN354B	Zinc-finger protein	Mono	Transcription regulation	[42]
LRRFIP1	GC-binding factor 2	Mono	Regulation of TNF expression	[42]
CD55	CD55	Mono	Complement decay-accelerating factor	[42]
MT-ND4L	Mitochondrially encoded NADH	Mono	Catalyses electron transfer from NADH	[42]
COL3A1	Collagens	Mono	Structural proteins in the ECM	[47, 48]
COL5A1	Collagens	Mono	Structural proteins in the ECM	[49]
COL6A2	Collagens	Mono	Structural proteins in the ECM	[50, 51]
FTH1P2	Ferritin	Poly	Intracellular iron storage	[52]
KYNU	Kynureninase	Poly	Biosynthesis of NAD cofactors
CXCL5	C-X-C motif chemokines	Poly	Important role in inflammation	[53,54,55]
CXCL9	C-X-C motif chemokines	Poly	Important role in inflammation	[53,54,55]
TGFBI	Kerato-Epithelin	Poly	Cell adhesion & ECM organisation	[42]
SLC11A1	Solute carrier family 11	Poly	Iron metabolism & host resistance	[42]
TAF1D	TBP-associated factor 1D	Poly	Component of transcription factor complex	[42]
TMSB4X	Thymosin Beta - 4	Poly	Organisation of cytoskeleton and actin monomers	[42]

Different genes were associated to different NSTI types, mono- and polymicrobial

ISSN: 1741-7015