Fig. 8

Focused panel association analysis results in blood. A The figure shows the significant differences in abundance of immune populations in the proliferative phase of the menstrual cycle in cases and controls. B Differences in abundance of populations between stages of endometriosis in blood. Analysis performed in the proliferative phase of the menstrual cycle. C UMAP from controls (red) and endometriosis (blue) samples, including both proliferative and secretory phases and both stages of the disease. Arrows show the cluster of highly activated non-classical monocytes. Y axis: Relative abundance of cells per cluster. The total cells per cluster represents all the cells from each specific population from all conditions analyzed (controls, endometriosis, proliferative and secretory phase). Ctrl: controls, Endo: endometriosis. Analysis performed in the proliferative phase of the menstrual cycle. p-values: *, p ≤ 0.05; **, p ≤ 0.005; **** p ≤ 0.00005. n = 6 controls and n = 13 endometriosis PE (8 mild stage and 5 severe stage). PE: proliferative