Fig. 2

Expression of TYW5 in different cell types of human and mouse brain and rs203772 may confer schizophrenia risk through regulating TYW5 expression. a TYW5 was expressed in different cell types (including neuron, microglia, oligodendrocytes, and astrocytes) of the human brain. b TYW5 was abundantly expressed in different cell types of a mouse brain, with the relatively high expression level in astrocytes and orbitofrontal cortex (OFC) cells. c, d Expression of TYW5 was relatively low at an early developmental stage. With the progress of development, TYW5 expression was gradually increased and peaked at the adult stage. c Expression data from the BrainSpan was used for plotting. d Expression data from the PsychENCODE was used for plotting. e Association of rs203772 with TYW5 expression in the 175 schizophrenia patients and 237 unaffected controls from DLPFC in BrainSeq Phase 1 dataset. f Association of rs203772 with TYW5 expression in the DLPFC from 397 individuals in BrainSeq Phase 2 dataset